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Metabolic Capacity of Israeli Populations

This study has been terminated.
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00162383
First received: September 11, 2005
Last updated: October 28, 2008
Last verified: October 2008
History of Changes

September 11, 2005
October 28, 2008
July 1995
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  • Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.
  • Frequency of genetic polymorphisms in these enzymes among different Israeli populations.
  • 1. Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism
  • 2. Frequency of genetic polymorphisms in these enzymes among different Israeli populations.
Complete list of historical versions of study NCT00162383 on ClinicalTrials.gov Archive Site
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Metabolic Capacity of Israeli Populations
Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition

The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions.

The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.
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Interventional
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Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Healthy Volunteers
  • Drug: Debrisoquine
  • Drug: Mephenytoin
  • Drug: Dapsone
  • Drug: Caffeine
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
1200
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Inclusion Criteria:

  • Age range 20-50
  • Absence of significant disease state

Exclusion Criteria:

  • The presence of significant disease states
  • The regular use of drugs (including birth control pills)
Both
20 Years to 50 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Israel
 
NCT00162383
yc19551-HMO-CTIL
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Hadassah Medical Organization
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Principal Investigator: Yoseph Caraco, MD Hadassah Medical Organization
Hadassah Medical Organization
October 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP