Analysis of Genetic Factors Which May Influence the Course of HIV Infection

This study has been completed.
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159068
First received: September 9, 2005
Last updated: June 22, 2011
Last verified: June 2010

September 9, 2005
June 22, 2011
February 2004
April 2011   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00159068 on ClinicalTrials.gov Archive Site
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Analysis of Genetic Factors Which May Influence the Course of HIV Infection
Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.

Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).

Observational
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

DNA isolated from peripheral blood.

Non-Probability Sample

Patients with HIV attending the HIV clinic at Hadassah colden globes.

HIV Infection
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Tang J, Kaslow RA. The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. AIDS. 2003;17 Suppl 4:S51-60. Review. No abstract available.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
150
April 2011
April 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • diagnosis of HIV

Exclusion Criteria:

  • under 18 years of age
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
NCT00159068
391200-HMO-CTIL
No
Deborah Rund, Hadassah Medical Organization
Hadassah Medical Organization
Not Provided
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
Hadassah Medical Organization
June 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP