Comparison of SCS and PMR in Patients With Refractory Angina Pectoris

This study has been terminated.
Sponsor:
Information provided by:
Medtronic
ClinicalTrials.gov Identifier:
NCT00157742
First received: September 9, 2005
Last updated: December 15, 2005
Last verified: September 2005

September 9, 2005
December 15, 2005
September 2000
Not Provided
Improvement in total exercice time following SCS compared to PMR at 12 months
Same as current
Complete list of historical versions of study NCT00157742 on ClinicalTrials.gov Archive Site
  • Angina measured by the CCS class and the patients subjectives observations
  • Morbidity/Mortality
  • Quality of life
  • Medication consumption
  • Difference in myocardial perfusion scanning
  • Myocardial ischemia during exercise treadmill testing
  • Safety profiles
Same as current
Not Provided
Not Provided
 
Comparison of SCS and PMR in Patients With Refractory Angina Pectoris
An Open Single-Centre Parallel Randomised Trial of Spinal Cord Stimulation (SCS) and Percutaneous Myocardial Revascularisation (PMR) in Patients With Refractory Angina Pectoris

Randomised trial of Spinal Cord Stimulation (SCS) and Percutaneous Myocardial Laser Revascularisation (PMR) in patients with Refractory Angina Pectoris.

Hypothesis: difference in exercise tolerance at 12 months between SCS and PMR

The purpose of this open, parallel, single-center prospective, randomised controlled trial is to compare two treatments: Spinal Cord Stimulation (SCS) and Percutaneous Myocardial Laser Revascularisation (PMR) and assess their use and longer term effect in patients with Refractory Angina Pectoris.

Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Angina Pectoris
  • Procedure: Spinal Cord Stimulation (SCS)
  • Procedure: Percutaneous Myocardial Laser Revascularisation (PMR)
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
66
January 2007
Not Provided

Inclusion Criteria:

  • Patient limiting angina (CCS III or IV) despite maximally tolerated medical therapy
  • Documented coronary artery disease (within the last 9 months prior baseline), which is unsuitable for conventional revascularisation techniques
  • Patient has documented reversible ischemia on nuclear scan (Tc-99 sestamibi)
  • Patient is limited in daily activities, primarily exercice capability, by their angina pain
  • Age 18 or older
  • Patient must understand the therapy and give informed consent
  • Patient must be available for appropriate follow-up times for length of Study
  • Non pregnant woman

Exclusion criteria:

  • Not candidate for surgical implantation of SCS and/or not for PMR and/or unable to use SCS device appropriately for treatment
  • Patient who has had one or more major cardiac events within 2 months
  • Patient with myocardial wall thickness< 8 mm in the ischaemic area to be treated as verified by echocardiography
  • Patient with extensive peripheral vascular disease that precludes vascular access required for PMR
  • Patient on intravenous therapy to control their symptoms
  • Patient who is unlikely to survive for more than 12 months due to non cardiac condition e.g.malignancy
  • patient who has other diseases that are considered of greater clinical significance than the angina pectoris that would impact the ability of the clinician to adequately assess the incremental effects of the trial treatment
  • Patient with ejection fraction of less than 30 % as verified by echocardiography
  • Patient with cause of angina other than coronary artery disease (e.g. syndrome "X" patient)
  • Patient who are unable to perform treadmill exercice test per protocol
  • Patient who was previously enrolled in this study, or is currently in another clinical study, which will interfere with this protocol
  • Patient who has has SCS , a TMLR or PMR procedure in the past
  • Patient with an implanted pacemaker or defibrillator
  • Patient who has medical conditions which may require Magnetic resonance Imaging (MRI)
  • Patient with history of dementia or other persisting mental disorders significantly interfering with ability to cooperate or comply with the requirements of the study or comprehend informed consent
  • Patient with history of Alcohol og Drug abuse
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00157742
SPIRIT
Not Provided
Not Provided
Medtronic
Not Provided
Principal Investigator: Peter Schofield, MD Papworth Hospital, NHS
Medtronic
September 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP