MR Scanning of Very Young Children With Severe Developmental Disorders

This study has been completed.
Sponsor:
Collaborators:
Netherlands Organisation for Scientific Research
The Dutch Brain Foundation
Information provided by:
UMC Utrecht
ClinicalTrials.gov Identifier:
NCT00156221
First received: September 8, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted

September 8, 2005
September 8, 2005
September 2000
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No Changes Posted
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MR Scanning of Very Young Children With Severe Developmental Disorders
MR Scanning of Very Young Children With Severe Developmental Disorders (Autistic Spectrum Disorders and/or Mental Retardation and/or Language Disorders)

The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.

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Observational
Observational Model: Natural History
Time Perspective: Cross-Sectional
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  • Autism
  • Mental Retardation
  • Language Disorder
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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September 2005
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Inclusion Criteria:

  • Age 18 months to 7 years
  • Diagnosis of autism spectrum disorder, a language disorder or mental retardation

Exclusion Criteria:

  • Significant motor or sensory impairment
  • Major physical abnormalities
  • History of serious head injury
  • Identifiable neurologic disorder
  • Metal implants
  • Contraindication for MRI
Both
18 Months to 7 Years
No
Contact information is only displayed when the study is recruiting subjects
Netherlands
 
NCT00156221
METC UMC Utrecht 99/184
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UMC Utrecht
  • Netherlands Organisation for Scientific Research
  • The Dutch Brain Foundation
Study Chair: Herman van Engeland, PhD, MD UMC Utrecht
Principal Investigator: Mijke Zeegers, Msc UMC Utrecht
UMC Utrecht
September 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP