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The Regulation of Osteoprotegerin by Mechanical Stimulation

This study is currently recruiting participants.
Study NCT00155311.   Last updated on November 25, 2005.   Information provided by National Taiwan University Hospital

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Descriptive Information Fields
Brief Title  The Regulation of Osteoprotegerin by Mechanical Stimulation
Official Title 
Brief Summary

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.

Detailed Description

Long treatment time is a major factor causing high fee for orthodontic treatment. Patients would have dental caries or periodontitis resulted from improper oral hygiene care during this long treatment period. Therefore, how to speed up the tooth movement which determines the duration of orthodontic treatment, can help more people to obtain good occlusion and esthetics. Orthodontic force on tooth induces bone resorption on the compression side and bone deposition on the tension side, thus bone remodels and then tooth moves. Bone resorption is a complex process. Osteoblasts play an important role during initiation of bone resorption.

Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling. In order to test this hypothesis, the following specific aims will be achieved:

  1. To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.
  2. To optimize the regulation by changing magnitude and frequency of pressure, and characterize the time table for these changes..
Study Phase Phase I
Study Type  Interventional
Study Design  Treatment, Non-Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study
Primary Outcome Measure  Tissue staining of antibody
Secondary Outcome Measure 
Condition  Malocclusion
Intervention  Procedure: orthodontic treatment
MEDLINE PMIDs
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Recruitment Information Fields
Recruitment Status  Recruiting
Enrollment  12
Start Date  January 2005
Completion Date December 2006
Eligibility Criteria 

Inclusion Criteria:

  • patients with two mandibular impaction third molars containing at least one mesially angular impaction with crown exposed to the oral cavity

Exclusion Criteria:

  • pregnancy or diseases with abnormal bone metabolism
Gender Both
Ages 18 Years to 35 Years
Accepts Healthy Volunteers Yes
Contacts ††
Contact: Chung-Chen Yao, DDS, PhD     886-2-23123456 ext 7689     janeyao@ha.mc.ntu.edu.tw    
Location Countries  Taiwan
Administrative Information Fields
NCT ID  NCT00155311
Organization ID 9361700741
Secondary IDs ††
Study Sponsor  National Taiwan University Hospital
Collaborators †† National Science Council, Taiwan
Investigators 
Principal Investigator:     Chung-Chen Yao, DDS, PhD     National Taiwan University Hospital    
Information Provided By National Taiwan University Hospital
Verification Date June 2004
First Received Date  September 8, 2005
Last Updated Date November 25, 2005

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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