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The Regulation of Osteoprotegerin by Mechanical Stimulation

This study is currently recruiting participants.

Study NCT00155311. Last updated on November 25, 2005. Information provided by National Taiwan University Hospital

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

The Regulation of Osteoprotegerin by Mechanical Stimulation

Official Title ^†

Brief Summary

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.

Detailed Description

Long treatment time is a major factor causing high fee for orthodontic treatment. Patients would have dental caries or periodontitis resulted from improper oral hygiene care during this long treatment period. Therefore, how to speed up the tooth movement which determines the duration of orthodontic treatment, can help more people to obtain good occlusion and esthetics. Orthodontic force on tooth induces bone resorption on the compression side and bone deposition on the tension side, thus bone remodels and then tooth moves. Bone resorption is a complex process. Osteoblasts play an important role during initiation of bone resorption.

Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling. In order to test this hypothesis, the following specific aims will be achieved:

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.
To optimize the regulation by changing magnitude and frequency of pressure, and characterize the time table for these changes..

Study Phase

Phase I

Study Type ^†

Interventional

Study Design ^†

Treatment, Non-Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study

Primary Outcome Measure ^†

Tissue staining of antibody

Secondary Outcome Measure ^†

Condition ^†

Malocclusion

Intervention ^†

Procedure: orthodontic treatment

MEDLINE PMIDs

Links

Recruitment Information Fields

Recruitment Status ^†

Recruiting

Enrollment ^†

Start Date ^†

January 2005

Completion Date

December 2006

Eligibility Criteria ^†

Inclusion Criteria:

patients with two mandibular impaction third molars containing at least one mesially angular impaction with crown exposed to the oral cavity

Exclusion Criteria:

pregnancy or diseases with abnormal bone metabolism

Gender

Both

Ages

18 Years to 35 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Contact: Chung-Chen Yao, DDS, PhD

886-2-23123456 ext 7689

janeyao@ha.mc.ntu.edu.tw

Location Countries ^†

Taiwan

Administrative Information Fields

NCT ID ^†

NCT00155311

Organization ID

9361700741

Secondary IDs ^††

Study Sponsor ^†

National Taiwan University Hospital

Collaborators ^††

National Science Council, Taiwan

Investigators ^†

Principal Investigator:

Chung-Chen Yao, DDS, PhD

National Taiwan University Hospital

Information Provided By

National Taiwan University Hospital

Verification Date

June 2004

First Received Date ^†

September 8, 2005

Last Updated Date

November 25, 2005

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.