| Home | Search | Study Topics | Glossary |
|
|
|
 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||
| Descriptive Information Fields | |||||||||||||
| Brief Title † | Objective Evaluation of Proximal Ischemia | ||||||||||||
| Official Title † | Effet Des Gestes de Revascularisation à l'étage Proximal | ||||||||||||
| Brief Summary | The whole study is divided in 4 parallel protocols. The first protocol estimates the reliability of the technique through test-retest recordings. The second protocol aims to prove that exercise Tcpo2 is efficient to estimate the benefit of proximal revascularisation on proximal and distal ischemia in patients suffering stage two lower extremity arterial disease. The third protocol aims at estimating with exercise tcpo2 the eventual apparison of proximal ischemia after aorto-bi-femoral bypasses. The last protocol is a transversal study of patients with aorto-bi-femoral bypasses aiming to analyse the presence of proximal and distal symptoms and ischemia. The hypothesis for protocol 2 is that TcpO2 at exercise is significantly improved after surgery at the aortic and primary iliac artery. The hypothesis for protocols 3 and 4 relates on the hypothesis that a significant number of patients benefiting aorto-bi-femoral bypass suffer isolated proximal pain/ischemia after surgery. Amendement to the project has been recently validated to study the neurologic and bone complication of chronic vascular ischemia |
||||||||||||
| Detailed Description | Patients included are submitted to: San Diego Claudication Questionnaire before and during the treadmill test Treadmill test(s) through the Strandness procedure (2MPh 10% slope) Transcutaneous oxygen pressure recording before during and after exercise Ankle and brachial pressure measurements. Neurologic investigation with Quantitative sensory Testing (QST) and neurophysiological tests for patients included in the sub-group analysing neurologic complication Whole body densitometry for patients included in the sub-group analysing osteo-articular complications |
||||||||||||
| Study Phase | |||||||||||||
| Study Type † | Observational | ||||||||||||
| Study Design † | Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study | ||||||||||||
| Primary Outcome Measure † | |||||||||||||
| Secondary Outcome Measure † | |||||||||||||
| Condition † | Intermittent Claudication Peripheral Vascular Diseases |
||||||||||||
| Intervention † | Procedure: Exercise test with Transcutaneous oxygene pressure Procedure: Ankle and arm pressure values Procedure: San diego claudication questionnaire |
||||||||||||
| MEDLINE PMIDs | 17264010, 17110509 | ||||||||||||
| Links | |||||||||||||
| Recruitment Information Fields | |||||||||||||
| Recruitment Status † | Recruiting | ||||||||||||
| Enrollment † | 165 | ||||||||||||
| Start Date † | March 2004 | ||||||||||||
| Completion Date | July 2008 | ||||||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
|
||||||||||||
| Gender | Both | ||||||||||||
| Ages | 18 Years and older | ||||||||||||
| Accepts Healthy Volunteers | No | ||||||||||||
| Contacts †† |
|
||||||||||||
| Location Countries † | France | ||||||||||||
| Administrative Information Fields | |||||||||||||
| NCT ID † | NCT00152737 | ||||||||||||
| Organization ID | PHRC 03-01 | ||||||||||||
| Secondary IDs †† | |||||||||||||
| Study Sponsor † | University Hospital, Angers | ||||||||||||
| Collaborators †† | Sanofi-Synthelabo Société Française de Médecine Vasculaire |
||||||||||||
| Investigators † |
|
||||||||||||
| Information Provided By | University Hospital, Angers | ||||||||||||
| Verification Date | March 2007 | ||||||||||||
| First Received Date † | September 8, 2005 | ||||||||||||
| Last Updated Date | March 16, 2007 | ||||||||||||
|
