Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance

This study has been completed.
Sponsor:
Collaborator:
Bayer
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT00139984
First received: August 29, 2005
Last updated: August 29, 2007
Last verified: July 2007

August 29, 2005
August 29, 2007
October 2003
Not Provided
Change in 24-hour systolic blood pressure from baseline to 1 year
  • Difference in mean 24-hour systolic blood pressure at 1 year
  • Difference in mean 24-hour diastolic blood pressure at 1 year
Complete list of historical versions of study NCT00139984 on ClinicalTrials.gov Archive Site
  • Change in 24-hour diastolic blood pressure from baseline to 1 year
  • Primary outcome measure in patients with treated hypertension at baseline
  • Proportion of patients with controlled hypertension at 1 year
  • Mean number of blood pressure lowering drugs per patient at 1 year
  • Difference in mean office systolic blood pressure at 1 year
  • Difference in mean office diastolic blood pressure at 1 year
Not Provided
Not Provided
 
Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance
Impact of Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance in Medical Outpatients: The Hyper-ABC Study

The purpose of this study is to determine whether in patients with arterial hypertension, treatment guidance using 24-hour blood pressure measurement results in better blood pressure control compared to treatment guidance using office blood pressure measurement.

Blood pressure control in arterial hypertension remains poor, despite the availability of effective drug treatment. Therefore, strategies to increase blood pressure control are urgently needed. 24 hour blood pressure is a better predictor of cardiovascular morbidity and mortality than office blood pressure. Furthermore, the lower variability of measurements over time of 24 hour blood pressure could allow better adjustment of antihypertensive therapy. However, there are only scarce data about antihypertensive treatment adjustment using 24 hour blood pressure instead of office blood pressure.

Aim: To test the hypothesis that a 24 hour blood pressure guided therapy is is more effective in reaching blood pressure control when compared to conventional office blood pressure guided therapy.

Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Hypertension
Device: 24 hour blood pressure measurement
Not Provided
Conen D, Tschudi P, Martina B. Twenty-four hour ambulatory blood pressure for the management of antihypertensive treatment: a randomized controlled trial. J Hum Hypertens. 2009 Feb;23(2):122-9. Epub 2008 Aug 28.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
170
May 2007
Not Provided

Inclusion Criteria:

  • Uncontrolled hypertension (office BP >139/89mmHg AND 24h BP >129/79mmHg)

Exclusion Criteria:

  • Severe concomitant illness including heart failure, significant valvular heart disease or malignancy
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
NCT00139984
EKBB183/03
No
Not Provided
University Hospital, Basel, Switzerland
Bayer
Principal Investigator: David Conen, MD Cardiology, University Hospital Basel
Principal Investigator: Benedict Martina, MD Medical Outpatient Clinic, University Hospital Basel
University Hospital, Basel, Switzerland
July 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP