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A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy

This study has been completed.
Sponsor:
Collaborator:
The Hypertension Trust
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00131807
First received: August 18, 2005
Last updated: April 25, 2007
Last verified: April 2007

August 18, 2005
April 25, 2007
September 2005
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Complete list of historical versions of study NCT00131807 on ClinicalTrials.gov Archive Site
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A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy
A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy

The purpose of this study is to explore the association between blood pressure, HIV and/or its treatment in a cross sectional observational study.

Deaths from AIDS have declined dramatically since the introduction of highly active antiretroviral therapy in HIV infected patients. However the incidence of heart disease has increased four-fold and is now one of the major causes of death in HIV infected patients. While HIV drugs are known to adversely affect serum lipids, the evidence concerning the association between raised blood pressure (a major risk for cardiovascular disease) HIV and/or its treatment is limited and conflicting. The researchers believe it of interest to study heart disease risk factors in patients with HIV infection to avoid one premature cause of death (AIDS) being replaced with another potentially preventable cause of death and disability (heart disease). In this cross sectional observational study the researchers will systematically measure blood pressure and other cardiovascular risk factors in HIV positive patients on and off antiretroviral therapy. These individuals will be matched for age, sex and ethnic group with HIV negative individuals.

Observational
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
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HIV Infections
  • Procedure: Blood Pressure Measurement
  • Procedure: Questionnaire
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
3000
September 2006
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Inclusion Criteria:

  • Attending St. Mary's sexual health outpatient department
  • Patients willing to give written informed consent
  • Ability to communicate in English

Exclusion Criteria:

  • Failure to give written informed consent in English
Both
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Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00131807
NPSW03
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Imperial College London
The Hypertension Trust
Principal Investigator: Neil R Poulter Imperial College London
Imperial College London
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP