| July 27, 2005 |
| July 1, 2009 |
| September 2004 |
| June 2010 (final data collection date for primary outcome measure) |
| Generalization of word retrieval skills [ Time Frame: 6 weeks following completion of treatment ] [ Designated as safety issue: No ] |
| The primary outcome measure is a metric that incorporates acquisition, response generalization within category, and response generalization across category effects. Probes of naming performance will be completed at 6 weeks post-treatment and performance. |
| Complete list of historical versions of study NCT00125242 on ClinicalTrials.gov Archive Site |
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- Naming of trained and untrained typical exemplars of trained categories.
- Naming of trained and untrained atypical exemplars of
- trained categories.
- Naming of exemplars of untrained categories.
- Production of information units in story retells.
- All of the above to be measured repeatedly throughout the
- course of the investigation as well as at 2 & 6 weeks post-tx.
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| |
| Word-Retrieval for Aphasia |
| Word-Retrieval for Aphasia: Facilitation of Generalization |
The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words. |
The purpose of the proposed research is to examine the effects of a semantically-oriented treatment on word retrieval in persons with aphasia. The planned investigations are designed to further the development of semantic feature training so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures. The proposed research will also address the issue of exemplar typicality (Kiran & Thompson, 2003) by examining the effects of training typical versus atypical exemplars of various categories with individuals with different types of aphasia. A series of 24 single subject experimental designs will be conducted in the context of a group design to address the following experimental questions:
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| |
| Interventional |
| Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
- Aphasia
- Language Disorders
- Speech Disorders
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| Behavioral: Semantic Feature Training |
| Other: single subject design (24 participants) |
| |
| |
| Recruiting |
| 24 |
| June 2010 |
| June 2010 (final data collection date for primary outcome measure) |
Inclusion Criteria:
- Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits
- At least 6 months post-onset of single, left-hemisphere stroke
- Minimum of high-school education
- Visual and auditory acuity sufficient for experimental tasks
- Nonverbal intelligence within normal limits
Exclusion Criteria:
- Diagnosed mental illness other than depression
- Neurological condition other than that which resulted in aphasia
- History of alcohol or substance abuse
- Non-native English speaker
- Premorbid history of speech/language disorder
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| Both |
| 21 Years to 75 Years |
| Yes |
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|
| United States |
| |
| NCT00125242 |
| Wambaugh, Julie - Principal Investigator, Department of Veterans Affairs |
| C3826R |
| Department of Veterans Affairs |
|
| Principal Investigator: |
Julie L Wambaugh |
VA Salt Lake City Health Care System, Salt Lake City |
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|
| Department of Veterans Affairs |
| July 2009 |