Improved Stroke Outcome at 6 Months

This study has been completed.
Sponsor:
Collaborator:
RehaClinic Zurzach
Information provided by:
Kantonsspital Baden
ClinicalTrials.gov Identifier:
NCT00122798
First received: July 21, 2005
Last updated: June 23, 2006
Last verified: December 2004

July 21, 2005
June 23, 2006
January 2002
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Complete list of historical versions of study NCT00122798 on ClinicalTrials.gov Archive Site
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Improved Stroke Outcome at 6 Months
Improved Stroke Outcome at 6 Months Attained by a Chain of Structured Acute Treatment With Integrated Rehabilitation and Supported Discharge

The investigators implemented a structured chain of acute stroke care with early integrated rehabilitation. The mortality at 6 months was lower (12%) compared to 23% in the International Stroke Trial (IST) and 39% (67%) of the patients were dead or dependent, which is superior compared to international data.

Background/Aim of the study: To further reduce the 6 months stroke morbidity and mortality in a high volume stroke hospital and to compare the results with national and international data.

Methods: 204 consecutive stroke patients are analyzed in a prospective study in a single center teaching institution. The intervention consists of a structured therapeutic chain of 290 collaborating GPs, a standardised acute hospital proceeding overlapping with an early integrated neurovascular rehabilitation within the same institution. Primary endpoints include death and dependence at 6 months, secondary endpoints are the length of hospital stay (LOS) and the quantitative analysis of physical and psychosocial impairments. The data are directly compared with the same endpoints of the Swiss subgroup of the international stroke trial (IST) and recent international data.

Results: At 6 months, mortality is significantly lower with 12 % (compared to 23 % in the IST trial) and only 39 % (67 %) of the patients are dead or dependent. Stroke severity is similar as in other study populations. Median LOS is 15 days in the acute clinic and 39 days in the rehabilitation institution. The psychosocial outcome compares favorably to a matched control group.

Conclusions: A structured chain of acute stroke treatment overlapping with an early integrated rehabilitation is superior compared to national and international ischemic stroke trial data.

Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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Stroke
Procedure: Stroke treatment
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
200
January 2005
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Inclusion Criteria:

  • An acute cerebrovascular event (ischemic stroke or intra-cerebral bleeding (ICB)) with the signs and symptoms of an acute stroke according to the World Health Organisation definition of acute stroke within the last 12 hours without the need or possibility of a neurosurgical intervention;
  • No thrombolytic therapy within the first 3 hours (in order to allow the correct comparison with the Swiss cohort of the IST trial)
  • The informed consent of the patient or, if not possible, of the next of kindred
  • Living at home before the event
  • Lack of participation in another trial

Exclusion Criteria:

  • Transient ischemic attack (TIA) resp. full recovery within 24 hours after the event
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
NCT00122798
EK 50
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Kantonsspital Baden
RehaClinic Zurzach
Principal Investigator: Juerg H Beer, M.D Dept of Medicine, Kantonsspital Baden, Switzerland
Kantonsspital Baden
December 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP