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Biological Effects of Dehydroepiandrosterone (DHEA) in the Elderly

This study has been completed.
Information provided by National Institute on Aging (NIA)

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Descriptive Information Fields
Brief Title  Biological Effects of Dehydroepiandrosterone (DHEA) in the Elderly
Official Title  Biological Effects of DHEA in the Elderly
Brief Summary

The purpose of the study is to examine whether DHEA replacement therapy is associated with beneficial changes in body composition (i.e., increases in lean mass and bone mass, and decreases in fat mass).

Detailed Description

The central hypothesis of this study is that restoring circulating levels of the adrenal hormone dehydroepiandrosterone (DHEA) in older people with low levels to more youthful levels will be associated with beneficial changes in lean mass, fat mass and bone mass.

This will be a randomized, placebo-controlled, double-blinded study. Seventy-two men and 72 women, over 60 years old, who are healthy, will be randomized to receive either a replacement dose of DHEA or placebo for 1 year. The replacement dose of DHEA will bring circulating DHEA sulfate (DHEAS) levels into the range of normal in healthy 20-30 year-old women (approximately 8 micromoles per liter [μM] or 295 micrograms per deciliter [µg/dL]) and men (approximately 10 micromoles per liter [μM] or 368 micrograms per deciliter [µg/dL]).

Fat mass and fat-free body mass will be evaluated by dual energy x-ray absorptiometry (DXA), and intra-abdominal fat volume and thigh muscle area will be measured by computed tomography (CT). Bone mineral density (BMD) of the total body, lumbar spine, and proximal femur will be measured by DXA and biochemical markers of bone resorption and formation. Glucose tolerance and insulin response will be evaluated using an oral glucose tolerance test.

If this study confirms the results of a previous preliminary study, the current study is likely to impact future scientific study regarding the role of DHEA deficiency in the biology of aging and its role as a therapeutic agent for the prevention of sarcopenia.

Study Phase
Study Type  Interventional
Study Design  Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Primary Outcome Measure  bone mineral density
body composition
Secondary Outcome Measure  blood lipids/lipoproteins
glucose tolerance
arterial compliance
visceral adiposity
quality of life
sex steroids and growth factors
sexual health
cognitive function
Condition  Healthy
Intervention  Drug: DHEA
MEDLINE PMIDs 16735495,   15536111,   14561100,   11932279,   10332570
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment  144
Start Date  August 2000
Completion Date March 2005
Eligibility Criteria 

Inclusion Criteria:

  • Healthy women and men
  • Age 60 or older
  • Age-appropriate DHEAS levels, but 70% lower than normal DHEAS levels for a 25-year old

Exclusion Criteria:

  • Contraindications to DHEA treatment (personal history of breast cancer or other estrogen-dependent neoplasms, acute liver disease, undiagnosed vaginal bleeding in women, history or evidence of prostate cancer or benign prostatic hyperplasia (BPH) in men)
  • Angina
  • Resting blood pressure over 180/95
  • Chronic infections
  • Hypothyroidism
  • Depression
  • Hormone therapy within the previous 6 months
  • Insulin-dependent or poorly controlled diabetes
  • Serum DHEAS level greater than 140 micrograms per deciliter (µg/dL)

Prohibited Medications:

  • Hormone therapy other than stable regimen of thyroid replacement
  • Oral glucocorticoids
  • Insulin
Gender Both
Ages 60 Years and older
Accepts Healthy Volunteers Yes
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00111930
Organization ID AG0019
Secondary IDs †† AG018857
Study Sponsor  National Institute on Aging (NIA)
Collaborators ††
Investigators 
Principal Investigator:     Wendy M. Kohrt, PhD     University of Colorado at Denver and Health Sciences Center    
Information Provided By National Institute on Aging (NIA)
Verification Date November 2006
First Received Date  May 26, 2005
Last Updated Date November 8, 2006

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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