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| Descriptive Information Fields | |||||
| Brief Title † | Osteoarthritis: Weakness From Inflammation | ||||
| Official Title † | Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis | ||||
| Brief Summary | The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging. |
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| Detailed Description | Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure. This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery. Participation in this study is entirely voluntary. |
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| Study Phase | |||||
| Study Type † | Observational | ||||
| Study Design † | Natural History | ||||
| Primary Outcome Measure † | |||||
| Secondary Outcome Measure † | |||||
| Condition † | Osteoarthritis | ||||
| Intervention † | |||||
| MEDLINE PMIDs | 10817551, 9811049, 10423192 | ||||
| Links | |||||
| Recruitment Information Fields | |||||
| Recruitment Status † | Recruiting | ||||
| Enrollment † | 60 | ||||
| Start Date † | April 2001 | ||||
| Completion Date | January 2007 | ||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||
| Ages | 50 Years and older | ||||
| Accepts Healthy Volunteers | No | ||||
| Contacts †† |
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| Location Countries † | United States | ||||
| Administrative Information Fields | |||||
| NCT ID † | NCT00104312 | ||||
| Organization ID | AG0016 | ||||
| Secondary IDs †† | |||||
| Study Sponsor † | National Institute on Aging (NIA) | ||||
| Collaborators †† | |||||
| Investigators † |
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| Information Provided By | National Institute on Aging (NIA) | ||||
| Verification Date | September 2007 | ||||
| First Received Date † | February 24, 2005 | ||||
| Last Updated Date | September 19, 2007 | ||||