Osteoarthritis: Weakness From Inflammation - Tabular View

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Osteoarthritis: Weakness From Inflammation

This study is currently recruiting participants.
Information provided by National Institute on Aging (NIA)

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

Osteoarthritis: Weakness From Inflammation

Official Title ^†

Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Brief Summary

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Detailed Description

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Study Phase

Study Type ^†

Observational

Study Design ^†

Natural History

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Osteoarthritis

Intervention ^†

MEDLINE PMIDs

10817551, 9811049, 10423192

Links

Recruitment Information Fields

Recruitment Status ^†

Recruiting

Enrollment ^†

Start Date ^†

April 2001

Completion Date

January 2007

Eligibility Criteria ^†

Inclusion Criteria:

50 years of age or older
Normal body weight (a Body Mass Index (BMI) of 30 or less)
Osteoarthritis of the knee (prior to knee surgery)
Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

History of a stroke
History of muscle weakness or paralysis
History of Rheumatoid Arthritis or
Inflammatory Joint Disease
History of a Bleeding Disorder
History of Gout
Diabetes for which you take insulin
Polymyalgia rheumatica (total body muscle aching/stiffness)

Gender

Both

Ages

50 Years and older

Accepts Healthy Volunteers

Contacts ^††

Contact: Edwina Rusch

410-350-3941 or 800-225-2572 ext 3941

ruschew@nia.nih.gov

Location Countries ^†

United States

Administrative Information Fields

NCT ID ^†

NCT00104312

Organization ID

AG0016

Secondary IDs ^††

Study Sponsor ^†

National Institute on Aging (NIA)

Collaborators ^††

Investigators ^†

Principal Investigator:

Shari Ling, MD

NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics

Information Provided By

National Institute on Aging (NIA)

Verification Date

September 2007

First Received Date ^†

February 24, 2005

Last Updated Date

September 19, 2007

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.