Osteoarthritis: Weakness From Inflammation - Tabular View

Tracking Information

First Received Date ^ICMJE

February 24, 2005

Last Updated Date

May 28, 2009

Start Date ^ICMJE

April 2001

Primary Completion Date

May 2009 (final data collection date for primary outcome measure)

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00104312 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Osteoarthritis: Weakness From Inflammation

Official Title ^ICMJE

Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Brief Summary

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Detailed Description

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Cohort, Cross-Sectional

Condition ^ICMJE

Osteoarthritis

Intervention ^ICMJE

Study Arms / Comparison Groups

Participants with symptomatic knee osteoarthritis
Participants without symptomatic knee osteoarthritis, age-matched as controls

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Estimated Enrollment ^ICMJE

Completion Date

May 2009

Primary Completion Date

May 2009 (final data collection date for primary outcome measure)

Eligibility Criteria ^ICMJE

Inclusion Criteria:

50 years of age or older
Normal body weight (a Body Mass Index (BMI) of 30 or less)
Osteoarthritis of the knee (prior to knee surgery)
Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

History of a stroke
History of muscle weakness or paralysis
History of Rheumatoid Arthritis or
Inflammatory Joint Disease
History of a Bleeding Disorder
History of Gout
Diabetes for which you take insulin
Polymyalgia rheumatica (total body muscle aching/stiffness)

Gender

Both

Ages

50 Years and older

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT ID ^ICMJE

NCT00104312

Responsible Party

Shari Ling, MD, Principal Investigator, National Institute on Aging

Study ID Numbers ^ICMJE

AG0016

Study Sponsor ^ICMJE

National Institute on Aging (NIA)

Collaborators ^ICMJE

Investigators ^ICMJE

Principal Investigator:

Shari Ling, MD

NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics

Information Provided By

National Institute on Aging (NIA)

Verification Date

May 2009

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP