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Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia

This study has been completed.
Sponsor:
Information provided by:
Eli Lilly and Company
ClinicalTrials.gov Identifier:
NCT00103571
First received: February 10, 2005
Last updated: November 5, 2007
Last verified: November 2007

February 10, 2005
November 5, 2007
July 2004
Not Provided
  • The primary objective of this study is to test the hypothesis that olanzapine is superior to aripiprazole in the reduction of symptoms of agitation in acutely ill patients with schizophrenia, as measured by mean change in the
  • Positive and Negative Syndrome Scale Excited Component (PANSS-EC) over 5 days of treatment (4 continuous 24 hr treatment exposures). The null hypothesis of the study is that there is no difference between olanzapine and
  • aripiprazole in reducing agitation.
Not Provided
Complete list of historical versions of study NCT00103571 on ClinicalTrials.gov Archive Site
  • The reduction in positive symptoms as measured by the Brief Psychiatric Rating Scale Positive subscale (PBRS Positive);
  • The reduction of symptoms of agitation as measured by Overt Agitation Severity Scale (OASS);
  • The proportion of patients responding to treatment and the time to response based on varying levels in the percent reduction of
  • the PANSS_EC from baseline;
  • The reduction in overall severity of psychiatric illness as measured by the Clinical Global Impression-Severity Scale (CGI-S);
  • The intensity of nursing intervention (e.g. seclusion, restraint, special nursing watch), as measured by the Global Assessment
  • of Nursing Intervention
  • The proportion of patients using pm lorazepam and the time-course of usage.
  • The proportion of patients discontinuing from the study due to lack of efficacy or due to adverse events related to worsening
  • of psychiatric illness.
  • Patient satisfaction with their medication, as measured by Drug Attitude Inventory (DA1-10).
  • A sensitivity analysis will be performed on two randomly chosen subsamples of the overall patient population by analyzing the
  • primary objective respectively.
  • Additional secondary objectives of the study are to compare the safety of olanzapine versus aripiprazole over the course of 5
  • days in the treatment of acutely ill patients with schizophrenia as assessed by:
  • Relative degree of sedation as measured by the Agitation Calmness Evalution Scale (ACES);
  • Review of spontaneous (unsolicited) treatment emergent adverse events;
  • Development of extrapyramidal symptoms as assessed by daily Modified Simpson-Angus and Barnes Akathisia scale scores.
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Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia
Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia

The purposes of this study are to assess similarities and differences in the efficacy (how well the drug works), safety, and side effects of olanzapine and aripiprazole in patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Schizophrenia
  • Drug: Olanzapine
  • Drug: Aripiprazole
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
600
August 2006
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Inclusion Criteria:

  • Patients must have schizophrenia, schizoaffective disorder, or schizophreniform disorder
  • Patients must be agitated
  • Patients must display psychotic symptoms
  • Patients must be inpatients who are expected to stay in the hospital for at least 5 days
  • Patients must be 18 to 55 years of age

Exclusion Criteria:

  • Patients may not be hospitalized for greater than 72 hours prior to study start
  • Patients may not have received more than one dose of olanzapine or aripiprazole within 72 hours prior to study start
  • Patients may not be actively suicidal
  • Patients may not be diagnosed with substance-induced psychosis or substance dependence
  • Patients may not have acute, serious, or unstable medical conditions
Both
18 Years to 55 Years
No
Contact information is only displayed when the study is recruiting subjects
United States,   Puerto Rico
 
NCT00103571
8928, F1D-US-HGLS
Not Provided
Not Provided
Eli Lilly and Company
Not Provided
Study Director: Call 1-877-CTLILLY(1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Eli Lilly and Company
Eli Lilly and Company
November 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP