Alopecia Areata Registry (NAAR)

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2014 by M.D. Anderson Cancer Center
Sponsor:
Collaborator:
National Alopecia Areata Foundation
Information provided by (Responsible Party):
M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier:
NCT00069589
First received: September 29, 2003
Last updated: October 27, 2014
Last verified: October 2014

September 29, 2003
October 27, 2014
November 2001
November 2099   (final data collection date for primary outcome measure)
Alopecia Areata Registry [ Time Frame: Registration on-going ] [ Designated as safety issue: No ]
Database registration of participants via collection of participant epidemiology data.
Not Provided
Complete list of historical versions of study NCT00069589 on ClinicalTrials.gov Archive Site
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Alopecia Areata Registry
Alopecia Areata Registry and Immunogenetic Mechanisms

Alopecia areata is the loss of hair in patches that can proceed to loss of all hair (alopecia totalis or universalis). The purpose of the registry is to collect patient information and blood samples from people with alopecia areata.

Alopecia areata is a condition in which hair is lost either from part of the scalp, all of the scalp, or the entire body, and it affects 1% to 2% of the population. It is thought to be an autoimmune disease and in some cases the disease is hereditary. The Alopecia Areata Registry will collect information and blood samples from clinically well-characterized patients with these three forms of alopecia areata: alopecia partialis (patchy loss of the scalp hair), alopecia totalis (total loss of all scalp hair), and alopecia universalis (complete loss of all hair everywhere on the body). This will be a collection of patients in multi-generational families, twins, single patients with patchy, persistent transient alopecia areata or long-standing alopecia totalis/universalis and with controls (persons unaffected and not related to alopecia patients). Information from these patients will be used to search the human genome for disease-associated loci and/or genes. Researchers interested in doing pathophysiology or treatment studies of this disease will also be able to contact patients having the appropriate form of the disease for the studies in question.

Patients who have been diagnosed with alopecia areata by a dermatologist will be eligible for the registry. Patients will fill out an information form online (alopeciaareataregistry.org). Patients who have a family history or specific types of alopecia will be invited to participate in a more detailed questionnaire and physical exam and have blood samples drawn.

Observational
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

DNA will be analyzed to learn the link between gene markers of traites of alopecia areata. Sera will be used to analyse cytokins. Lymphocytes will be used for the creation of B-cell lines.

Probability Sample

Patients with alopecia areata (AA), both children and adults, who have been diagnosed by a physician with alopecia universalis, alopecia totalis, patchy persistent AA, or transient mild AA. Family members (related by blood) of these patients, preferably sib-pairs plus parents and multiplex families(persons with at least three family members with AA or alopecia universalis and alopecia totalis).

Also, healthy individuals who are unaffected, non-blood related individuals and do not live in the same household with alopecia areata patient are needed as controls.

  • Alopecia Areata
  • Alopecia Totalis
  • Alopecia Universalis
  • Autoimmune Hair Loss
  • Alopecia Partialis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
3100
November 2099
November 2099   (final data collection date for primary outcome measure)

Inclusion Criteria

  • Diagnosed with alopecia areata by a dermatologist
  • United States resident

Accepts Health Volunteers: Non blood-related individuals who are unaffected with alopecia areata and do not live in the same household with alopecia areata patient.

Both
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Yes
Contact: Alopecia Areata Registry Patient Recruitment 713-792-5999 alopeciaregistry@mdanderson.org
Contact: Alopecia Areata Registry Toll Free Number 1-866-837-1050
United States
 
NCT00069589
NIAMS-097, HHSN268200682279C
No
M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
National Alopecia Areata Foundation
Principal Investigator: Madeleine Duvic, MD M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
October 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP