Resistance to HIV Infection

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by National Institute of Allergy and Infectious Diseases (NIAID).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov Identifier:
NCT00069485
First received: September 26, 2003
Last updated: September 17, 2007
Last verified: July 2007

September 26, 2003
September 17, 2007
December 1995
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Complete list of historical versions of study NCT00069485 on ClinicalTrials.gov Archive Site
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Resistance to HIV Infection
Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals

The immune systems of some individuals may be capable of resisting HIV infection. These individuals do not appear to be infected with HIV despite multiple sexual encounters with HIV infected partners. This study will examine the immune systems of these individuals to determine what factors are responsible for their ability to resist HIV infection.

Study hypothesis: Some long-term, multiply-exposed seronegative persons have relative resistance to HIV infection maintained by T cell responses.

Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique population in which to evaluate mechanisms by which HIV-1 replication is either controlled or aborted. The purpose of the study is to analyze HIV-specific immune responses, both cellular and humoral, that exist in seronegative individuals who have experienced multiple exposures to HIV by sexual contact.

This study will follow participants for 2 years. Participants will have 25 study visits during the study. Assessments will include HIV tests, viral load measurements, CD4 counts, pregnancy tests, and physical exams.

Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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HIV Infections
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
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Inclusion Criteria:

  • Good general health
  • HIV uninfected
  • Repeated exposures to HIV through unprotected sexual intercourse within the 2 years prior to study entry
  • Live in the greater Seattle area
  • Plan to stay in the greater Seattle area for the 2 years after study entry

Exclusion Criteria:

  • Pregnancy
Both
18 Years to 60 Years
Yes
United States
 
NCT00069485
5R01AI47086-03, 5 R01 AI47086-03
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National Institute of Allergy and Infectious Diseases (NIAID)
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Principal Investigator: Julie McElrath, MD, PhD University of Washington
National Institute of Allergy and Infectious Diseases (NIAID)
July 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP