Genetic Registry for Rheumatoid Arthritis (NARAC)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Arthritis Foundation
Information provided by (Responsible Party):
Peter Gregersen, Feinstein Institute for Medical Research
ClinicalTrials.gov Identifier:
NCT00069472
First received: September 25, 2003
Last updated: October 9, 2013
Last verified: July 2013

September 25, 2003
October 9, 2013
October 2002
December 2013   (final data collection date for primary outcome measure)
Genetic Association with risk for rheumatoid arthritis [ Time Frame: 3 years ] [ Designated as safety issue: No ]
The project aims to identify one or more risk alleles for rheumatoid arthritis using association methods in trio families, combeined with data from singleton cases and multiplex families
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Complete list of historical versions of study NCT00069472 on ClinicalTrials.gov Archive Site
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Genetic Registry for Rheumatoid Arthritis
Genetics of Rheumatoid Arthritis Registry

Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

Observational
Observational Model: Family-Based
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

DNA, plasma, serum and cells

Non-Probability Sample

Persons with RA who have two living biological parents. Parents can be affected or unaffected with RA. We call the family units "trios".

Rheumatoid Arthritis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
3000
July 2015
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adult onset RA
  • Diagnosis of RA made between 18 and 60 years old
  • Both parents alive and willing to participate
  • Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

  • Inflammatory bowel disease
  • Lupus
  • Psoriatic arthritis
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00069472
NIAMS-107, N01AR72232-001
No
Peter Gregersen, Feinstein Institute for Medical Research
North Shore Long Island Jewish Health System
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  • Arthritis Foundation
Principal Investigator: Peter K. Gregersen, MD North Shore University Hospital
North Shore Long Island Jewish Health System
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP