Treatment Response to Rehabilitation in Patients With Schizophrenia

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
Hartford Hospital
ClinicalTrials.gov Identifier:
NCT00063336
First received: June 25, 2003
Last updated: November 7, 2013
Last verified: May 2009

June 25, 2003
November 7, 2013
December 2001
November 2005   (final data collection date for primary outcome measure)
  • Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities [ Time Frame: Measured pre- and post-treatment ] [ Designated as safety issue: No ]
  • Schizophrenia symptoms [ Time Frame: Measured pre- and post-treament ] [ Designated as safety issue: No ]
  • UCSD Performance-Based Skills Assessment [ Time Frame: Measured pre- and post-treatment ] [ Designated as safety issue: No ]
Not Provided
Complete list of historical versions of study NCT00063336 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Treatment Response to Rehabilitation in Patients With Schizophrenia
Treatment Response to Rehabilitation in Schizophrenia

This study will examine the ways in which schizophrenia-related symptoms affect response to a rehabilitation program for people with schizophrenia.

Patients with schizophrenia often suffer neurocognitive impairment and psychosocial and vocational difficulties. This study will help identify those patients most likely to benefit from existing behavioral treatments and provide clues for how to modify treatments for those who do not benefit.

Two studies will be conducted. The first will investigate the relationship of symptoms and neurocognitive variables at study entry to psychosocial and vocational status 2 years later. The second study will investigate the relationship of symptoms and neurocognitive variables at study entry to treatment response in patients assigned to either a cognitive remediation track or a computer skills track as part of their rehabilitation treatment.

Both the cognitive remediation and computer skills training programs will last 4 to 6 months. Participants will be assessed pre- and post-treatment. Neuropsychological, psychosocial and vocational status will be measured.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
Schizophrenia
  • Behavioral: Cognitive Remediation
    A computerized cognitive rehabilitation treatment with day-program activities
  • Behavioral: Computer-skills training
    A computerized cognitive rehabilitation treatment with day-program activities
  • Experimental: 1
    Participants will receive cognitive remediation treatment.
    Intervention: Behavioral: Cognitive Remediation
  • Experimental: 2
    Participants will receive computer-skills training.
    Intervention: Behavioral: Computer-skills training
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
46
November 2005
November 2005   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • DSM-IV criteria for schizophrenia or schizoaffective disorder
  • In need of intensive outpatient care
  • Treatment with atypical antipsychotic medication for a minimum of 6 months prior to study entry

Exclusion Criteria:

  • Auditory or visual impairment
  • Mental retardation (IQ less than 70)
  • Traumatic brain injury with loss of consciousness
  • Presence or history of any neurological illness that may affect brain physiology
  • Lack of proficiency in English
  • Concurrent substance abuse and/or dependence
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00063336
R03 MH065377, R03MH065377, DSIR AT-SP
Not Provided
Matthew M. Kurtz, PhD, Schizophrenia Rehabilitation Program, Institutes of Living
Hartford Hospital
National Institute of Mental Health (NIMH)
Principal Investigator: Matthew M. Kurtz, PhD Schizophrenia Rehabilitation Program, Institutes of Living
Hartford Hospital
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP