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Therapy for Depressed Elders With Thought Problems

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT00052091
First received: January 22, 2003
Last updated: September 20, 2013
Last verified: September 2013

January 22, 2003
September 20, 2013
September 2002
March 2008   (final data collection date for primary outcome measure)
Hamilton Rating Scale for Depression [ Time Frame: Measured at screening, weeks 1 through 12, and week 36 ] [ Designated as safety issue: Yes ]
Not Provided
Complete list of historical versions of study NCT00052091 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Therapy for Depressed Elders With Thought Problems
PST in Geriatric Depression With Executive Dysfunction

This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.

Patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. It is important, therefore, to find effective alternative therapies to treat these symptoms.

Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
  • Depression
  • Cognition Disorders
  • Behavioral: Problem Solving Therapy
    A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
  • Behavioral: Brief Supportive Therapy
    A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.
  • Experimental: 1 Problem Solving Therapy
    12 weekly sessions of problem solving therapy (PST)
    Intervention: Behavioral: Problem Solving Therapy
  • Experimental: 2 Brief Supportive Therapy
    12 weekly sessions of brief supportive therapy (BST)
    Intervention: Behavioral: Brief Supportive Therapy

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
221
March 2008
March 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Nonpsychotic, unipolar major depression
  • Cognitive impairment
  • English speaking

Exclusion Criteria:

  • High suicide risk
  • Dementia
  • Acute or severe medical illness
  • Current psychotherapy
Both
60 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00052091
R01 MH063982, R01MH063982, DATR A4-GPS
Not Provided
University of California, San Francisco
University of California, San Francisco
National Institute of Mental Health (NIMH)
Principal Investigator: Patricia A. Arean, PhD University of California at San Francisco
University of California, San Francisco
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP