Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity - Tabular View

Tracking Information
First Received Date ^ICMJE	July 18, 2002
Last Updated Date	March 22, 2006
Start Date ^ICMJE	September 2000
Primary Completion Date
Current Primary Outcome Measures ^ICMJE
Original Primary Outcome Measures ^ICMJE
Change History	Complete list of historical versions of study NCT00041821 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ^ICMJE
Original Secondary Outcome Measures ^ICMJE

Descriptive Information
Brief Title ^ICMJE	Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity
Official Title ^ICMJE	Individual Factors in Nasal Irritant Sensitivity
Brief Summary	This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).
Detailed Description
Study Phase
Study Type ^ICMJE	Interventional
Study Design ^ICMJE	Randomized, Single Blind, Crossover Assignment
Condition ^ICMJE	Rhinitis, Allergic, Nonseasonal
Intervention ^ICMJE	Procedure: Nasal irritation thresholds and irritant provocation
Study Arms / Comparison Groups
Publications *	Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9.
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE	64
Completion Date
Primary Completion Date
Eligibility Criteria ^ICMJE	Inclusion Criteria: Non-smokers 18-69 years of age With or without allergic rhinitis (hay fever) In good general health and with no prior history of asthma
Gender	Both
Ages	18 Years to 69 Years
Accepts Healthy Volunteers	Yes
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	United States

Administrative Information
NCT ID ^ICMJE	NCT00041821
Responsible Party
Study ID Numbers ^ICMJE	10424-CP-001
Study Sponsor ^ICMJE	National Institute of Environmental Health Sciences (NIEHS)
Collaborators ^ICMJE
Investigators ^ICMJE
Information Provided By	National Institute of Environmental Health Sciences (NIEHS)
Verification Date	March 2006
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP