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Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer
This study is ongoing, but not recruiting participants.
Study NCT00039507   Information provided by National Cancer Institute (NCI)
First Received: June 6, 2002   Last Updated: February 6, 2009   History of Changes

June 6, 2002
February 6, 2009
June 2002
 
 
 
Complete list of historical versions of study NCT00039507 on ClinicalTrials.gov Archive Site
 
 
 
Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer
Pilot Study: Radiofrequency Ablation Of Resectable Non-Small Cell Lung Cancer

RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combining radiofrequency ablation with surgery in treating patients who have stage I or stage II non-small cell lung cancer.

OBJECTIVES:

  • Determine the acute effects of intraoperative radiofrequency tumor ablation (RFA) in patients with resectable non-small cell lung cancer.
  • Determine the treatment-related toxicity in patients treated with this therapy.
  • Determine the dimensions of the RFA lesion produced by the ablation procedure in these patients.

OUTLINE: Patients undergo intraoperative radiofrequency tumor ablation over 10-15 minutes for each tumor immediately followed by tumor resection.

PROJECTED ACCRUAL: A maximum of 20 patients will be accrued for this study.

Phase II
Interventional
Treatment
Lung Cancer
  • Procedure: conventional surgery
  • Procedure: radiofrequency ablation
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Active, not recruiting
 
 
 

DISEASE CHARACTERISTICS:

  • Diagnosis of malignant non-small cell lung cancer (NSCLC)

    • Intraoperative needle biopsy confirmation allowed
  • Resectable disease (stage I or II)
  • All tissue to be treated by radiofrequency tumor ablation must be completely contained within boundaries of planned lung resection
  • Medically fit to undergo lung resection

PATIENT CHARACTERISTICS:

Age:

  • Over 18

Performance status:

  • Not specified

Life expectancy:

  • Not specified

Hematopoietic:

  • Not specified

Hepatic:

  • Not specified

Renal:

  • Not specified

Other:

  • Not pregnant or nursing

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • No prior or concurrent biologic therapy

Chemotherapy:

  • No prior or concurrent chemotherapy

Endocrine therapy:

  • No prior or concurrent endocrine therapy

Radiotherapy:

  • No prior or concurrent radiotherapy

Surgery:

  • See Disease Characteristics

Other:

  • No other prior therapy for NSCLC
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00039507
 
CDR0000069389, FCCC-02007, NCI-G02-2079
Fox Chase Cancer Center
National Cancer Institute (NCI)
Study Chair: Walter J. Scott, MD, FACS Fox Chase Cancer Center
National Cancer Institute (NCI)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP