Genome Scan for Obesity in a Multi-Ethnic Sample - Tabular View

Tracking Information
First Received Date ^ICMJE	May 16, 2002
Last Updated Date	June 23, 2005
Start Date ^ICMJE	April 2001
Primary Completion Date
Current Primary Outcome Measures ^ICMJE
Original Primary Outcome Measures ^ICMJE
Change History	Complete list of historical versions of study NCT00037271 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ^ICMJE
Original Secondary Outcome Measures ^ICMJE

Descriptive Information
Brief Title ^ICMJE	Genome Scan for Obesity in a Multi-Ethnic Sample
Official Title ^ICMJE
Brief Summary	To scan the genome for obesity in a multi-ethnic sample.
Detailed Description	BACKGROUND: Despite intensive efforts the genetic basis of obesity has been difficult to establish. Linkage analysis using a genome-wide scan can potentially identify genomic regions not previously thought to be associated with susceptibility to obesity and provides a comprehensive test of the consistency of previous studies. The study used the considerable resources generated by the four cooperating networks in the NHLBI-supported "Family Blood Pressure Program" (FBPP) to conduct a genome-wide scan data for obesity. DESIGN NARRATIVE: In the Family Blood Pressure Program, microsatellite markers were typed at a density of -10cM by the Mammalian Genotyping Service (MGS) in Marshfield, WI. The complete data set was to include 9,940 individuals representing 4 ethnic groups (white, black, Hispanic and Asian). Obesity was characterized as a weight/height ratio (body mass index) and waist/hip ratio. This data set was larger than any prior genome scan for obesity, and the inclusion of multiple ethnic groups made it possible to examine genetic heterogeneity. The specific aims of the study were to conduct linkage and association analyses to localize regions influencing obesity. Investigators worked closely with the FBPP Coordinating Center (Washington University, St. Louis) and investigators from each of the four FBPP networks. Evidence was sought for consistency between results obtained from analyses of the genome scan performed by each of the individuals, and results summarized from the literature, with those found in meta-analysis.
Study Phase
Study Type ^ICMJE	Observational
Study Design ^ICMJE	Natural History, Defined Population
Condition ^ICMJE	Cardiovascular Diseases Heart Diseases Obesity
Intervention ^ICMJE
Study Arms / Comparison Groups
Publications *	Zhu X, Cooper RS, Luke A, Chen G, Wu X, Kan D, Chakravarti A, Weder A. A genome-wide scan for obesity in African-Americans. Diabetes. 2002 Feb;51(2):541-4. Zhu X, Zhang S, Zhao H, Cooper RS. Association mapping, using a mixture model for complex traits. Genet Epidemiol. 2002 Aug;23(2):181-96. Wu X, Cooper RS, Borecki I, Hanis C, Bray M, Lewis CE, Zhu X, Kan D, Luke A, Curb D. A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hum Genet. 2002 May;70(5):1247-56. Zhu X, Chang YP, Yan D, Weder A, Cooper R, Luke A, Kan D, Chakravarti A. Associations between hypertension and genes in the renin-angiotensin system. Hypertension. 2003 May;41(5):1027-34. Epub 2003 Apr 14. Huang J, Jiang Y. Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs. Am J Hum Genet. 2003 Apr;72(4):949-60. Epub 2003 Mar 17. Zhu X, Yan D, Cooper RS, Luke A, Ikeda MA, Chang YP, Weder A, Chakravarti A. Linkage disequilibrium and haplotype diversity in the genes of the renin-angiotensin system: findings from the family blood pressure program. Genome Res. 2003 Feb;13(2):173-81. Zhu X, Cooper RS. Linkage disequilibrium analysis of the renin-angiotensin system genes. Curr Hypertens Rep. 2003 Feb;5(1):40-6. Review.
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE
Completion Date	March 2003
Primary Completion Date
Eligibility Criteria ^ICMJE	No eligibility criteria
Gender	Both
Ages
Accepts Healthy Volunteers	No
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE

Administrative Information
NCT ID ^ICMJE	NCT00037271
Responsible Party
Study ID Numbers ^ICMJE	1158
Study Sponsor ^ICMJE	National Heart, Lung, and Blood Institute (NHLBI)
Collaborators ^ICMJE
Investigators ^ICMJE
Information Provided By	National Heart, Lung, and Blood Institute (NHLBI)
Verification Date	August 2004
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP