Collaborative Study of 1,3 Butadiene Biomarkers - Tabular View

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Collaborative Study of 1,3 Butadiene Biomarkers

This study has been completed.
Information provided by National Institute of Environmental Health Sciences (NIEHS)

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields
Brief Title ^†	Collaborative Study of 1,3 Butadiene Biomarkers
Official Title ^†
Brief Summary	Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.
Detailed Description
Study Phase
Study Type ^†	Observational
Study Design ^†	Natural History, Longitudinal, Defined Population, Prospective Study
Primary Outcome Measure ^†
Secondary Outcome Measure ^†
Condition ^†	Cancer
Intervention ^†
MEDLINE PMIDs
Links

Recruitment Information Fields
Recruitment Status ^†	Completed
Enrollment ^†	80
Start Date ^†	July 1999
Completion Date	December 2002
Eligibility Criteria ^†	Healthy adults without metabolic disorders
Gender	Both
Ages	19 Years to 65 Years
Accepts Healthy Volunteers	Yes
Contacts ^††
Location Countries ^†	United States, Taiwan

Administrative Information Fields
NCT ID ^†	NCT00023140
Organization ID	9401-CP-001
Secondary IDs ^††
Study Sponsor ^†	National Institute of Environmental Health Sciences (NIEHS)
Collaborators ^††
Investigators ^†
Information Provided By	National Institute of Environmental Health Sciences (NIEHS)
Verification Date	March 2006
First Received Date ^†	August 22, 2001
Last Updated Date	March 22, 2006

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.