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Collaborative Study of 1,3 Butadiene Biomarkers

This study has been completed.
Information provided by National Institute of Environmental Health Sciences (NIEHS)

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Descriptive Information Fields
Brief Title  Collaborative Study of 1,3 Butadiene Biomarkers
Official Title 
Brief Summary

Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.

Detailed Description
Study Phase
Study Type  Observational
Study Design  Natural History, Longitudinal, Defined Population, Prospective Study
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  Cancer
Intervention 
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment  80
Start Date  July 1999
Completion Date December 2002
Eligibility Criteria 

Healthy adults without metabolic disorders

Gender Both
Ages 19 Years to 65 Years
Accepts Healthy Volunteers Yes
Contacts ††
Location Countries  United States,   Taiwan
Administrative Information Fields
NCT ID  NCT00023140
Organization ID 9401-CP-001
Secondary IDs ††
Study Sponsor  National Institute of Environmental Health Sciences (NIEHS)
Collaborators ††
Investigators 
Information Provided By National Institute of Environmental Health Sciences (NIEHS)
Verification Date March 2006
First Received Date  August 22, 2001
Last Updated Date March 22, 2006

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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