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Chemoprevention With Folic Acid
This study has been completed.
Study NCT00018551   Information provided by Department of Veterans Affairs
First Received: July 3, 2001   Last Updated: January 20, 2009   History of Changes

July 3, 2001
January 20, 2009
October 1998
 
 
 
Complete list of historical versions of study NCT00018551 on ClinicalTrials.gov Archive Site
 
 
 
Chemoprevention With Folic Acid
3389 Colorectal Adenoma: Chemoprevention With Folic Acid

Colorectal neoplasia is the second most common cancer in the United States and other Western countries with about 140,000 newly diagnosed cases per year in the United States with a mortality rate of about 40%. The identification of a specific natural or synthetic compound with the ability to reverse or suppress the process of colon carcinogenesis would have profound implication in the development of colorectal adenomas and their subsequent transformation to colon cancer. Furthermore, the establishment of a correlative relationship between biomarkers of cell proliferation, differentiation, apoptosis and adenoma recurrence would provide pivotal data required to elucidate cell signaling mechanisms in future colon cancer chemoprevention trials.

 
Phase II
Interventional
Prevention, Randomized, Double-Blind, Placebo Control, Efficacy Study
  • Colon Cancer
  • Adenoma
  • Colonic Polyps
Drug: Folic Acid
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
 
September 2003
 

Asymptomatic individuals from the age of 18 -80 years, undergoing clinically indicated colonoscopy for colon polyps noted on screening flexible sigmoidoscopy or as routine surveillance for a history of colon polyps, who are found to have at least one adenoma > 0.5cm will be eligible for entry.

Both
18 Years to 80 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00018551
 
ONCO-021-98S
Department of Veterans Affairs
 
 
Department of Veterans Affairs
December 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP