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Brain Excitability During Self-Paced Voluntary Movements
This study has been completed.
Study NCT00017966   Information provided by National Institutes of Health Clinical Center (CC)
First Received: June 23, 2001   Last Updated: March 3, 2008   History of Changes

June 23, 2001
March 3, 2008
June 2001
 
 
 
Complete list of historical versions of study NCT00017966 on ClinicalTrials.gov Archive Site
 
 
 
Brain Excitability During Self-Paced Voluntary Movements
Cortical Excitability During Self-Paced Voluntary Movements

This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease. Normal healthy volunteers 18 years of age and older may be eligible to participate.

In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's scalp or skin. Brief electrical currents are passed through the coil, creating magnetic pulses that stimulate the brain. During the stimulation, participants will be asked to tense certain muscles slightly or perform other simple actions. The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle. In most cases, the study will last less than 3 hours.

The purpose of this study is to investigate the influence of volitional movement on excitability of ipsilateral as well as contralateral motor cortical neurons controlling homologous and surrounding muscles. Transcallosal and surrounding inhibitions are well known phenomenon to suppress unwanted movements during voluntary action, which is often disturbed in various movement disorders. Transcranial magnetic stimulation (TMS) has been used to investigate these inhibitory mechanisms, but the inhibitory influence during and after voluntary movement has not been well elucidated yet. In normal volunteers, we plan to determine if voluntary movements of one finger influence the cortical excitability responsible for surrounding as well as contralateral homologous muscles, using voluntary movement-triggered TMS. The primary outcome measures would be any changes in motor evoked potential (MEP) size and intracortical inhibition (ICI) parameters.

 
Observational
 
  • Movement Disorder
  • Healthy
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
30
June 2002
 

Normal adult volunteers 18 or more years old.

Subjects must not have medico-surgical illness.

Subjects must not have neurological illness.

Subjects must not have psychiatric illness.

Subjects must not be taking any medication with potential influence on nervous system function.

Subjects must not have a pacemaker.

Subject must not have an implanted medical pump.

Subjects must not have a metal plate or a metal object in the skull or eye.

Subjects must not have a history of seizure disorder.

Both
 
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00017966
 
010199, 01-N-0199
National Institute of Neurological Disorders and Stroke (NINDS)
 
 
National Institutes of Health Clinical Center (CC)
June 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP