Dichloroacetate Kinetics, Metabolism and Toxicology - Tabular View

Tracking Information
First Received Date ^ICMJE	April 17, 2001
Last Updated Date	September 1, 2006
Start Date ^ICMJE	December 1994
Primary Completion Date
Current Primary Outcome Measures ^ICMJE
Original Primary Outcome Measures ^ICMJE
Change History	Complete list of historical versions of study NCT00015015 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ^ICMJE
Original Secondary Outcome Measures ^ICMJE

Descriptive Information
Brief Title ^ICMJE	Dichloroacetate Kinetics, Metabolism and Toxicology
Official Title ^ICMJE
Brief Summary	Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.
Detailed Description
Study Phase
Study Type ^ICMJE	Observational
Study Design ^ICMJE	Screening, Longitudinal, Defined Population, Prospective Study
Condition ^ICMJE	Lactic Acidosis
Intervention ^ICMJE	Drug: Dichloroacetate
Study Arms / Comparison Groups
Publications *
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE	100
Completion Date	October 2002
Primary Completion Date
Eligibility Criteria ^ICMJE	Children with congenital lactic acidosis Healthy adult volunteers
Gender	Both
Ages	3 Months to 65 Years
Accepts Healthy Volunteers	Yes
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	United States

Administrative Information
NCT ID ^ICMJE	NCT00015015
Responsible Party
Study ID Numbers ^ICMJE	7355-CP-001
Study Sponsor ^ICMJE	National Institute of Environmental Health Sciences (NIEHS)
Collaborators ^ICMJE
Investigators ^ICMJE
Information Provided By	National Institute of Environmental Health Sciences (NIEHS)
Verification Date	September 2006
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP