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| Descriptive Information Fields | |||||
| Brief Title † | A Medication Adherence Intervention for HIV Infected Veterans | ||||
| Official Title † | A Medication Adherence Intervention for HIV Infected Veterans | ||||
| Brief Summary | It is estimated that the VHA is caring for nearly 40 percent of all HIV-infected veterans. To benefit from recent improvements in anti-HIV therapy, patients need to take their medications consistently. |
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| Detailed Description | Background: It is estimated that the VHA is caring for nearly 40 percent of all HIV-infected veterans. To benefit from recent improvements in anti-HIV therapy, patients need to take their medications consistently. Objectives: Optimizing health for HIV patients requires excellent adherence to antiretroviral medication regimens. However, its unclear how best to incorporate adherence education and support programs into VA HIV outpatient care. We implemented and evaluated a pharmacist program (ACE) and a Pager reminder program to support adherence in veterans with HIV. Methods: We used a quasi-experimental design with pre-post evaluation at four VA Centers. Three treatment conditions (ACE, Pager, Usual Care) were rolled-in sequentially over two study phases, allowing for group comparisons between conditions. ACE is a multi-component manualized 4-session, individual patient education and support program by trained pharmacists. The Pager intervention used alphanumeric pagers to remind patients of dosing times. Electronically-monitored medication adherence (MEMS), self-report questionnaires, and pharmacy refill records were collected. Qualitative site interviews were collected before and after interventions to assist with program evaluation. Multilevel mixed models were used to analyze main study outcomes over time. Secondary analyses compared subgroup who actually received all ACE sessions (�as treated�) to controls. Status: Project has been completed and Final Report submitted to HSR&D CO. |
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| Study Phase | |||||
| Study Type † | Observational | ||||
| Study Design † | Prospective | ||||
| Primary Outcome Measure † | |||||
| Secondary Outcome Measure † | |||||
| Condition † | HIV Infection | ||||
| Intervention † | |||||
| MEDLINE PMIDs | 12562043, 12458308 | ||||
| Links | |||||
| Recruitment Information Fields | |||||
| Recruitment Status † | Completed | ||||
| Enrollment † | 210 | ||||
| Start Date † | |||||
| Completion Date | December 2003 | ||||
| Eligibility Criteria † | Inclusion Criteria: Patients must be greater than or equal to 18 years old, must be enrolled in HIV Primary care at one of 4 VA study sites and be taking antiretroviral therapy. Exclusion Criteria: |
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| Gender | Both | ||||
| Ages | 18 Years to 65 Years | ||||
| Accepts Healthy Volunteers | No | ||||
| Contacts †† | |||||
| Location Countries † | United States | ||||
| Administrative Information Fields | |||||
| NCT ID † | NCT00013065 | ||||
| Organization ID | HII 99-054 | ||||
| Secondary IDs †† | |||||
| Study Sponsor † | Department of Veterans Affairs | ||||
| Collaborators †† | |||||
| Investigators † |
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| Information Provided By | Department of Veterans Affairs | ||||
| Verification Date | January 2005 | ||||
| First Received Date † | March 14, 2001 | ||||
| Last Updated Date | October 31, 2008 | ||||
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