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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Arthritis Foundation
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00008749
First received: January 16, 2001
Last updated: June 23, 2005
Last verified: December 2003

January 16, 2001
June 23, 2005
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Complete list of historical versions of study NCT00008749 on ClinicalTrials.gov Archive Site
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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.

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Observational
Observational Model: Case Control
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Lupus Erythematosus, Systemic
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
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Inclusion:

A diagnosis of systemic lupus erythematosus

Both
13 Years and older
Yes
Contact: Randy Q Cron, MD, Ph.D. 215-590-1844
United States
 
NCT00008749
NCRR-M01RR00240-1736
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National Center for Research Resources (NCRR)
Arthritis Foundation
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National Center for Research Resources (NCRR)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP