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Dose/Response of Exercise on Long Term Weight Loss

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00006315
First received: September 28, 2000
Last updated: June 23, 2005
Last verified: May 2005

September 28, 2000
June 23, 2005
September 1999
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Complete list of historical versions of study NCT00006315 on ClinicalTrials.gov Archive Site
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Dose/Response of Exercise on Long Term Weight Loss
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To examine the dose-response of exercise on long-term weight loss in overweight adult women.

BACKGROUND:

Exercise is a key component of behavioral weight loss programs because of its effect on weight loss, body composition, cardiovascular disease risk factors, and other obesity related diseases such as type 2 diabetes mellitus. Despite these benefits, it is unclear whether there is an optimal exercise duration and/or intensity that will enhance long-term weight loss. The current public health recommendation for physical activity is for individuals to participate in at least 30 minutes of moderate intensity physical activity on most days of the week (approximately 150 minutes per week total). However, it is unclear whether this amount of exercise is adequate for long-term weight loss. Moreover, cross-sectional studies have shown that individuals that have been successful at long-term weight loss participate in levels of physical activity that are greater than the current public health recommendations.

DESIGN NARRATIVE:

The researchers hypothesized that adopting higher levels of exercise duration and/or intensity, coupled with a strong behavioral intervention would enhance long-term weight loss. To test this hypothesis, they recruited 200 overweight women and randomly assigned them to one of four treatment groups: (1) moderate intensity, moderate 1000cal/wk duration exercise, (2) vigorous intensity moderate duration exercise, (3) moderate 2000cal/wk intensity, high duration exercise, and (4) vigorous intensity, high duration exercise. All subjects participated in a 24-month behavioral weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the interventionists. In addition, to facilitate the adoption of the exercise protocols, all subjects were provided with a home treadmill. Assessment of body weight occured at 0, 6, 12, and 24 months and exercise participation was measured throughout the program. In addition, body composition, cardiorespiratory fitness, cardiovascular disease risk factors, and mediators of behavior change were measured at 0, 6, 12, and 24 months.

Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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  • Cardiovascular Diseases
  • Heart Diseases
  • Obesity
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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August 2004
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No eligibility criteria

Female
25 Years to 45 Years
No
Contact information is only displayed when the study is recruiting subjects
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NCT00006315
923
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National Heart, Lung, and Blood Institute (NHLBI)
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Investigator: John Jakicic University of Pittsburgh
National Heart, Lung, and Blood Institute (NHLBI)
May 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP