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| Descriptive Information Fields | |
| Brief Title † | The Effect of Estrogen and Progesterone Levels on Knee and Ankle Joint Laxity |
| Official Title † | |
| Brief Summary | The proposed research is an observational study designed to compare estrogen and progesterone serum levels with knee and ankle joint laxity, and muscle reaction time as a measure of neuromuscular function. Three groups of women athletes with differing estrogen and progesterone profiles (normal menstrual cycles, amenorrheic, and exogenous estrogen supplementation) and one control group (male collegiate athletes) will be used to compare differences in joint laxity and neuromuscular function. Blood levels of estrogen and progesterone will be measured at four time points across the menstrual cycle. Joint laxity and muscle reaction time will also be measured at each of these points. The investigator hypothesizes that knee and ankle joint laxity and muscle reaction time will significantly increase with increasing estrogen and progesterone levels. |
| Detailed Description | |
| Study Phase | |
| Study Type † | Observational |
| Study Design † | Natural History |
| Primary Outcome Measure † | |
| Secondary Outcome Measure † | |
| Condition † | Healthy |
| Intervention † | |
| MEDLINE PMIDs | |
| Links | |
| Recruitment Information Fields | |
| Recruitment Status † | Active, not recruiting |
| Enrollment † | |
| Start Date † | |
| Completion Date | |
| Eligibility Criteria † | Inclusion Criteria:
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| Gender | Both |
| Ages | 15 Years to 23 Years |
| Accepts Healthy Volunteers | Yes |
| Contacts †† | |
| Location Countries † | United States |
| Administrative Information Fields | |
| NCT ID † | NCT00005923 |
| Organization ID | NCRR-M01RR00109-0749 |
| Secondary IDs †† | M01RR00109 |
| Study Sponsor † | National Center for Research Resources (NCRR) |
| Collaborators †† | |
| Investigators † | |
| Information Provided By | National Center for Research Resources (NCRR) |
| Verification Date | November 2001 |
| First Received Date † | June 23, 2000 |
| Last Updated Date | June 23, 2005 |