Prospective Study of HIV Infection in Hemophiliacs - Tabular View

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Prospective Study of HIV Infection in Hemophiliacs

This study has been completed.

Study NCT00005309. Last updated on June 23, 2005. Information provided by National Heart, Lung, and Blood Institute (NHLBI)

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

Prospective Study of HIV Infection in Hemophiliacs

Official Title ^†

Brief Summary

To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.

Detailed Description

BACKGROUND:

In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.

DESIGN NARRATIVE:

Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.

Study Phase

Study Type ^†

Observational

Study Design ^†

Natural History

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Acquired Immunodeficiency Syndrome
HIV Infections
Blood Disease
Hemophilia A
Hepatitis, Viral, Human
Blood Transfusion
Cytomegalovirus Infections

Intervention ^†

MEDLINE PMIDs

Links

Recruitment Information Fields

Recruitment Status ^†

Completed

Enrollment ^†

Start Date ^†

July 1990

Completion Date

March 1995

Eligibility Criteria ^†

No eligibility criteria

Gender

Male

Ages

Accepts Healthy Volunteers

Contacts ^††

Location Countries ^†

Administrative Information Fields

NCT ID ^†

NCT00005309

Organization ID

3012

Secondary IDs ^††

Study Sponsor ^†

National Heart, Lung, and Blood Institute (NHLBI)

Collaborators ^††

Investigators ^†

Investigator:

George Gjerset

Puget Sound Blood Center

Information Provided By

National Heart, Lung, and Blood Institute (NHLBI)

Verification Date

March 2005

First Received Date ^†

May 25, 2000

Last Updated Date

June 23, 2005

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.