The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

This study has been completed.
Sponsor:
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
NCT00002276
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: June 1990

November 2, 1999
June 23, 2005
Not Provided
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00002276 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia
Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Not Provided
Interventional
Not Provided
Primary Purpose: Treatment
  • HIV Infections
  • Hemophilia A
  • Drug: Ibuprofen
  • Drug: Zidovudine
Not Provided
Ragni MV, Miller BJ, Whalen R, Ptachcinski R. Bleeding tendency, platelet function, and pharmacokinetics of ibuprofen and zidovudine in HIV(+) hemophilic men. Am J Hematol. 1992 Jul;40(3):176-82.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
Not Provided
Not Provided

Inclusion Criteria

Patients must have:

  • Hemophilia.
  • HIV-seropositivity confirmed by Western Blot.

Prior Medication:

Required:

- AZT for study patients.

Allowed:

- Ibuprofen.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms and conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection or malignancy.

Concurrent Medication:

Excluded:

  • AZT (for control group).
  • Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy.

Patients with the following prior conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection, or malignancy.

Required:

  • Ibuprofen.
  • AZT 1-2 gm daily (for study patient) or not taking AZT (for control).
Both
12 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00002276
044A
Not Provided
Not Provided
University of Pittsburgh
Not Provided
Not Provided
NIH AIDS Clinical Trials Information Service
June 1990

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP