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Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

This study has been completed.
Study NCT00002052.   Last updated on June 23, 2005.   Information provided by NIH AIDS Clinical Trials Information Service

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Descriptive Information Fields
Brief Title  Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients
Official Title  Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients
Brief Summary

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

Detailed Description
Study Phase
Study Type  Interventional
Study Design  Treatment, Dose Comparison
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  HIV Infections
Salmonella Infections
Intervention  Drug: Ceftriaxone sodium
Drug: Ampicillin sodium
Drug: Amoxicillin trihydrate
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment 
Start Date 
Completion Date
Eligibility Criteria 

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

  • Type I hypersensitivity to beta-lactam antibiotics.
  • Not expected to survive 12 weeks.
  • In a coma or with other central nervous system (CNS) impairment.

Patients with the following are excluded:

  • Type I hypersensitivity to beta-lactam antibiotics.
  • Not expected to survive 12 weeks.
  • In a coma or with other central nervous system (CNS) impairment.

Prior Medication:

Excluded within 48 hours of study entry:

  • Treatment with an antibiotic active in vitro against Salmonella.

HIV infection, AIDS, or AIDS related complex (ARC).

  • Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.
Gender Both
Ages 18 Years and older
Accepts Healthy Volunteers No
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00002052
Organization ID 019A
Secondary IDs ††
Study Sponsor  University of Southern California
Collaborators ††
Investigators 
Information Provided By NIH AIDS Clinical Trials Information Service
Verification Date August 1989
First Received Date  November 2, 1999
Last Updated Date June 23, 2005

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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