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| Descriptive Information Fields | |
| Brief Title † | Areas of Brain Responsible for Understanding American Sign Language |
| Official Title † | Hemispheric Lateralization of Language Receptive Function in the Deaf and in Hearing Individuals Who Learned ASL as First Language |
| Brief Summary | The human brain is made up of two halves called hemispheres. Each half of the brain is responsible for processing different kinds of information. Previous neuroimaging studies have shown that both the right and left hemispheres are involved when processing information given in American Sign Language (ASL). However, the study also showed that when processing spoken language, the left hemisphere was mostly involved. Researchers would like to find out more about how the brain processes American Sign Language (ASL). This study is designed to determine if the right hemisphere is necessary for normal understanding of ASL. |
| Detailed Description | The purpose of this protocol is to determine if the right hemisphere activation associated with perception of American Sign Language (ASL) in deaf subjects and in normal hearing individuals raised by deaf parents (who learned ASL before written English) is necessary for appropriate understanding of ASL. |
| Study Phase | |
| Study Type † | Observational |
| Study Design † | |
| Primary Outcome Measure † | |
| Secondary Outcome Measure † | |
| Condition † | Brain Mapping Deafness Healthy |
| Intervention † | |
| MEDLINE PMIDs | 9448260, 1718723 |
| Links | |
| Recruitment Information Fields | |
| Recruitment Status † | Completed |
| Enrollment † | 30 |
| Start Date † | March 1998 |
| Completion Date | December 2000 |
| Eligibility Criteria † | Subject age between 18 and 65 years. Adult hearing offsprings of deaf parents. Congenitally deaf individuals. Intact hearing volunteers. No subjects with personal or family history of seizures or other neurological or demyelinating disorders. No pregnant women tested after urine pregnancy test. No subjects with severe coronary disease. No subjects with metal in the cranium except mouth. No subjects with intracardiac lines and implanted medication pumps. No subjects with increased intracranial pressure as evaluated by clinical means. No subjects with cardiac pacemakers. No subjects with an intake of neuroleptics. |
| Gender | Both |
| Ages | |
| Accepts Healthy Volunteers | Yes |
| Contacts †† | |
| Location Countries † | United States |
| Administrative Information Fields | |
| NCT ID † | NCT00001782 |
| Organization ID | 980082 |
| Secondary IDs †† | 98-N-0082 |
| Study Sponsor † | National Institute of Neurological Disorders and Stroke (NINDS) |
| Collaborators †† | |
| Investigators † | |
| Information Provided By | National Institutes of Health Clinical Center (CC) |
| Verification Date | November 1999 |
| First Received Date † | November 3, 1999 |
| Last Updated Date | March 3, 2008 |
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