Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001500
First received: November 3, 1999
Last updated: March 3, 2008
Last verified: July 2004

November 3, 1999
March 3, 2008
April 1996
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Complete list of historical versions of study NCT00001500 on ClinicalTrials.gov Archive Site
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Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.

Observational
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  • Acquired Immunodeficiency Syndrome
  • Alcoholism
  • HIV Infection
  • Neoplasm
  • Smoking
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
4500
July 2004
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INCLUSION CRITERIA:

The basic requirement for entry in the study will be the presence of any individual smoker who is willing to complete the evaluation process and donate a blood sample.

Additional siblings will be encouraged but not required to participate.

Probands will be recruited through smoking cessation programs at the National Naval Medical Center.

Attendees at programs offered by the Health Promotions Department and the Military Family Health Center will be invited to participate in this study.

EXCLUSION CRITERIA:

All subjects will be adults (greater than 18 years).

There will be no exclusions based on sex, ethnic group, or race.

Both
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Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00001500
960061, 96-C-0061
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National Cancer Institute (NCI)
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National Institutes of Health Clinical Center (CC)
July 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP