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| Descriptive Information Fields | |||||||||
| Brief Title † | Study and Treatment of Inflammatory Muscle Diseases | ||||||||
| Official Title † | Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases | ||||||||
| Brief Summary | This study of inflammatory muscle diseases-polymyositis and dermatomyositis and related disorders-will examine what causes these diseases and describe the clinical features (signs and symptoms) associated with them. Inflammation and degeneration of skeletal muscles in these disorders leads to weakness and muscle wasting. The skin, lungs and other organs may also be involved. Patients 16 years of age and older with polymyositis, dermatomyositis, or a related disorder may be eligible for this study. Participants will undergo a complete history and physical examination, including routine blood and urine tests. Additional procedures for diagnosis, treatment or research may include:
Patients who are eligible for experimental treatment studies will be offered the opportunity to join them. Others will be advised of treatment recommendations. |
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| Detailed Description | Polymyositis, dermatomyositis and related disorders, also known as the idiopathic inflammatory myopathies (IIM), are an uncommon, heterogenous group of diseases. This is an omnibus protocol designed to continue our description of this rare group of diseases, further delineate important groups of patients, and obtain useful material for further study on the immunological abnormalities, pathogenesis and etiology of IIM. Often the diagnosis of an IIM can be confused with other illness (such as adult-onset dystrophies), and therefore, we will be evaluating patients with other illnesses (who are referred with a preliminary diagnosis of an IIM). Patients evaluated with IIM will receive with informed consent the best standard therapies available and consideration for entry into any therapeutic protocols. MRI will be performed on healthy volunteers to help develop a mathematical method for quantitating edema of muscle MRI in patients. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | |||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Autoimmune Disease Dermatomyositis Inclusion Body Myositis Myositis Polymyositis |
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| Intervention † | |||||||||
| MEDLINE PMIDs | 1090839, 2662848 | ||||||||
| Links | NIH Clinical Center Detailed Web Page ![]() |
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | |||||||||
| Start Date † | August 1991 | ||||||||
| Completion Date | |||||||||
| Eligibility Criteria † |
Patients with known or suspected idiopathic inflammatory myopathies (IIM) or patients with other connective tissue diseases with weakness or myalgias for an inflammatory myopathy or other muscle process. EXCLUSION: None other than inclusion criteria. |
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| Gender | Both | ||||||||
| Ages | 16 Years and older | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00001265 | ||||||||
| Organization ID | 910196 | ||||||||
| Secondary IDs †† | 91-AR-0196 | ||||||||
| Study Sponsor † | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | ||||||||
| Collaborators †† | |||||||||
| Investigators † | |||||||||
| Information Provided By | National Institutes of Health Clinical Center (CC) | ||||||||
| Verification Date | April 2008 | ||||||||
| First Received Date † | November 3, 1999 | ||||||||
| Last Updated Date | August 19, 2008 | ||||||||