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| Descriptive Information Fields | |||||||||
| Brief Title † | Resistance to Vitamin D or Parathyroid Hormone | ||||||||
| Official Title † | Studies of States With Resistance to Vitamin D and Parathyroid Hormone | ||||||||
| Brief Summary | Patients with confirmed or suspected conditions with a resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment, and inclusion in other studies pertaining to similar conditions. This study will provide information about problems relating to calcium in the blood, urine, and bones. Patients in this study will undergo a general evaluation / check-up to give researchers an idea of each person's condition or disease. Patients will receive treatment based on their diagnosis and asked to provide specimen samples for further research studies. |
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| Detailed Description | Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Resistance to a factor is manifested by deficient bioeffect despite high levels of the factor in blood. Patients will be tested with multiple indices of mineral metabolism to establish the diagnosis and examine the spectrum of the underlying disorder. The principal therapies will be combinations of calcium, phosphate, and a vitamin D analog. Selected patients will have localization and surgery to remove a tumor that causes renal wasting of phosphate. Patients will be considered for entry into other research protocols. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | |||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Hypocalcemia Osteomalacia Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Rickets |
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| Intervention † | |||||||||
| MEDLINE PMIDs | 6893458, 1862138 | ||||||||
| Links | NIH Clinical Center Detailed Web Page  |
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | |||||||||
| Start Date † | September 1989 | ||||||||
| Completion Date | |||||||||
| Eligibility Criteria † |
Patients of any age or sex with vitamin D resistance, rickets, osteomalacia, pseudohypoparathyroidism, pseudo-pseudohypoparathyroidism, or suspicion of these or related disorders based upon the appropriateness of their problem to ongoing investigations. Current investigations are focused primarily upon subjects with target tissue resistance to 1,25-dihydroxyvitamin D, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism. |
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| Gender | Both | ||||||||
| Ages | 1 Year and older | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00001242 | ||||||||
| Organization ID | 890173 | ||||||||
| Secondary IDs †† | 89-DK-0173 | ||||||||
| Study Sponsor † | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | ||||||||
| Collaborators †† | |||||||||
| Investigators † | |||||||||
| Information Provided By | National Institutes of Health Clinical Center (CC) | ||||||||
| Verification Date | June 2008 | ||||||||
| First Received Date † | November 3, 1999 | ||||||||
| Last Updated Date | July 19, 2008 | ||||||||
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