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| Descriptive Information Fields | |
| Brief Title † | Genetic Studies in Alzheimer's Disease |
| Official Title † | Biochemical and Genetic Studies in Familial Alzheimer's Disease |
| Brief Summary | Alzheimer's disease is a condition marked by the deterioration of mental function. The disease usually begins in late middle life and results in death in 5 to 10 years. Patients with Alzheimer's disease typically suffer from memory loss, confusion, and disorientation. The condition has become a major medical and social problem in the United States because of the increasing number of people living beyond the age of 65. The actual cause of Alzheimer's disease is unknown. Researchers believe that Alzheimer's disease, or at least a portion of cases, may be an inherited condition. As a result, many new techniques have been developed to study the genetic causes of Alzheimer's disease and other neurological disorders. Many of these genetic techniques require blood samples and a family pedigree. A pedigree is a chart, similar to a family tree, that shows a patient's family history. The purpose of this study is to collect family and psychosocial information, blood, and biopsy samples from patients with neurological diseases, their families, and normal volunteers. This information gathered will be used to learn more about diseases that affect the brain. |
| Detailed Description | This is a screening and follow-up Protocol. Recent technological advances have facilitated the development of new approaches for investigating the underlying genetic basis of neurological disorders, but genetic questions remain open and on going. Application of many genetic techniques require a family pedigree and blood sample. Peripheral blood lymphoblasts which are banked also serve as a renewable source for harvesting DNA which can be used for developing genetic markers in the future. This study will allow collection of family and psychosocial information and blood specimens from patients with neurological diseases, their families, and normal control subjects. |
| Study Phase | |
| Study Type † | Observational |
| Study Design † | |
| Primary Outcome Measure † | |
| Secondary Outcome Measure † | |
| Condition † | Alzheimer's Disease Nervous System Disease |
| Intervention † | |
| MEDLINE PMIDs | 6600923, 7596406, 7732429 |
| Links | |
| Recruitment Information Fields | |
| Recruitment Status † | Completed |
| Enrollment † | 1500 |
| Start Date † | February 1988 |
| Completion Date | February 2004 |
| Eligibility Criteria † | INCLUSION/EXCLUSION CRITERIA Need to know extensive family history information. |
| Gender | Both |
| Ages | |
| Accepts Healthy Volunteers | Yes |
| Contacts †† | |
| Location Countries † | United States |
| Administrative Information Fields | |
| NCT ID † | NCT00001235 |
| Organization ID | 880029 |
| Secondary IDs †† | 88-N-0029 |
| Study Sponsor † | National Institute of Neurological Disorders and Stroke (NINDS) |
| Collaborators †† | |
| Investigators † | |
| Information Provided By | National Institutes of Health Clinical Center (CC) |
| Verification Date | February 2004 |
| First Received Date † | November 3, 1999 |
| Last Updated Date | March 3, 2008 |
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