The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders - Tabular View

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The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders

This study has been completed.

Study NCT00001232. Last updated on March 3, 2008. Information provided by National Institutes of Health Clinical Center (CC)

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Descriptive Information Fields
Brief Title ^†	The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
Official Title ^†	Pituitary Gonadotropin Response to GnRH Stimulation in Menstrual, Climacteric and, Menopause-Related Mood and Behavioral Disorders
Brief Summary	The normal menstrual cycle is produced by a series of hormonal signals that starts with the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The hypothalamus is located in the brain and is often referred to as the master gland. GnRH then acts on the pituitary gland and causes it to release two hormones, follicle stimulating hormone (FSH) and lutenizng hormone (LH). LH and FSH act on the ovary and cause it to release the hormones directly involved in menstruation, estrogen and progesterone. The purpose of this research study is to evaluate the hypothalamic-pituitary-gonadal axis activity as measured by pituitary hormones, FSH and LH in response to intravenous doses of gonadotropin releasing hormone (GnRH) in menstrual cycle-related hormones.
Detailed Description	This protocol is designed to accompany clinical protocol #81-M-0126, "The Phenomenology and Biophysiology of Menstrually Regulated Mood and Behavior Disorders", as well as the submitted protocol, "The Phenomenology and Biophysiology of Climacteric and Menopause-Related Mood and Behavioral Disorders." Its purpose will be to evaluate hypothalamic-pituitary-gonadal axis regulation as measured by pituitary gonadotropin, i.e., follicle stimulating hormone (FSH) and luteinizing hormone (LH), response to intravenous administration of gonadotropin releasing hormone (GnRH) in menstrual cycle-related mood disorders.
Study Phase
Study Type ^†	Observational
Study Design ^†
Primary Outcome Measure ^†
Secondary Outcome Measure ^†
Condition ^†	Depressive Disorder Healthy Mental Disorders Mood Disorders
Intervention ^†
MEDLINE PMIDs	2962499, 8828428, 8774283
Links

Recruitment Information Fields
Recruitment Status ^†	Completed
Enrollment ^†	140
Start Date ^†	July 1988
Completion Date	June 2000
Eligibility Criteria ^†	Age 18-65. Female. Use of barrier methods of birth control. Not pregnant. Not taking ongoing medications. No medical illnesses.
Gender	Female
Ages
Accepts Healthy Volunteers	Yes
Contacts ^††
Location Countries ^†	United States

Administrative Information Fields
NCT ID ^†	NCT00001232
Organization ID	880132
Secondary IDs ^††	88-M-0132
Study Sponsor ^†	National Institute of Mental Health (NIMH)
Collaborators ^††
Investigators ^†
Information Provided By	National Institutes of Health Clinical Center (CC)
Verification Date	July 1999
First Received Date ^†	November 3, 1999
Last Updated Date	March 3, 2008

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.