Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.

This study has been completed.
Sponsor:
Information provided by:
National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov Identifier:
NCT00000830
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: March 1998

November 2, 1999
June 23, 2005
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Complete list of historical versions of study NCT00000830 on ClinicalTrials.gov Archive Site
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Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.
Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.

To determine the levels of zidovudine triphosphate ( AZT-TP ) in maternal and fetal cord blood mononuclear cells. To determine the ratio of AZT-TP to endogenous nucleoside triphosphate levels in maternal and fetal cells. To determine the extent of drug transfer through the feto/placental unit.

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Observational
Observational Model: Natural History
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  • HIV Infections
  • Pregnancy
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Rodman JH, Flynn PM, Robbins BL, Blanchard S, Jimenez E, Rodriguez J, Fridland A. Zidovudine pharmacokinetics and intracellular pharmacology of zidovudine in HIV-infected women and newborn infants. Conf Retroviruses Opportunistic Infect. 1999 Jan 31-Feb 4;6th:146 (abstract no 419)

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
24
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Female
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States,   Puerto Rico
 
NCT00000830
ACTG 296
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National Institute of Allergy and Infectious Diseases (NIAID)
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Study Chair: Fridland A
Study Chair: Flynn P
National Institute of Allergy and Infectious Diseases (NIAID)
March 1998

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP