Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection

This study has been completed.
Sponsor:
Collaborator:
Andrulis Pharmaceuticals
Information provided by (Responsible Party):
National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov Identifier:
NCT00000790
First received: November 2, 1999
Last updated: March 30, 2012
Last verified: March 2012

November 2, 1999
March 30, 2012
Not Provided
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00000790 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection

PRIMARY: To evaluate the effectiveness and safety of thalidomide for treatment of oral and esophageal aphthous ulcers (those unrelated to a known infection or malignancy) in patients with advanced HIV disease. To evaluate the effect of thalidomide on HIV load in this patient population. Per 06/28/94 amendment, to evaluate the effectiveness of thalidomide in preventing recurrences in patients whose aphthae completely heal at the end of acute treatment.

SECONDARY: To evaluate the effect of thalidomide on blood tumor necrosis factor (TNF) levels and to obtain pharmacokinetic data on the drug. Per 06/28/94 amendment, to evaluate the safety of thalidomide. Per 05/10/95 amendment, to explore in a substudy the effects of thalidomide on idiopathic genital aphthous ulcers in HIV-infected women.

Aphthous ulcers of the mouth or esophagus can interfere with eating, resulting in malnutrition and wasting. Thalidomide has been proposed as an effective therapy for severe forms of aphthous ulceration in AIDS patients.

Aphthous ulcers of the mouth or esophagus can interfere with eating, resulting in malnutrition and wasting. Thalidomide has been proposed as an effective therapy for severe forms of aphthous ulceration in AIDS patients.

Patients are randomized to receive 4 weeks of either thalidomide or placebo orally, administered once daily. Patients are followed weekly. Complete responders after 4 weeks of acute treatment enter a 24-week maintenance phase. A pharmacokinetic substudy will be included.

Interventional
Phase 2
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
  • HIV Infections
  • Stomatitis, Aphthous
Drug: Thalidomide
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
164
October 1998
Not Provided

Inclusion Criteria

Concurrent Medication:

Allowed:

  • Anti-HIV therapy provided therapy has remained constant in the 4 weeks prior to study entry.
  • Narcotic analgesia after the first week of treatment ONLY IF the patient is not experiencing somnolence.

Patients must have:

  • Documented HIV infection or AIDS.
  • Biopsy-confirmed aphthous ulceration of the mouth or esophagus lasting at least 2 weeks.
  • Negative culture of ulcer for Herpes simplex.
  • En face diameter of >= 5 mm for largest aphthous ulcer.
  • Life expectancy of at least 3 months.

NOTE:

  • This study is approved for prisoner participation.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

  • Known allergy to thalidomide.
  • Grade 2 or worse bilateral peripheral neuropathy.

EXCLUDED FOR MAINTENANCE PHASE:

  • Toxicity other than somnolence in acute phase that required discontinuation of drug.

Concurrent Medication:

Excluded:

  • Acute therapy for opportunistic infection.
  • ddC.
  • Pentoxifylline.
  • Methotrexate, trimetrexate, antineoplastic alkylating agents.
  • Other putative immunomodulators.
  • CNS depressants and/or medications with sedative or hypnotic effect.
  • Systemic and/or oral topical corticosteroids.
  • Systemic chemotherapy for Kaposi's sarcoma or other malignancies.
  • Compounded antibacterial mouthwashes containing anti-infective agents (such as doxycycline, minocycline, tetracycline, or nystatin).

Concurrent Treatment:

Excluded:

  • Radiation to head and/or neck.

Patients with the following prior conditions are excluded:

  • History of grade 2 or worse bilateral peripheral neuropathy.
  • Change in anti-HIV therapy within 4 weeks prior to study entry.
  • Prior enrollment in ACTG 251 or prior treatment of aphthous ulcers with thalidomide.

Prior Medication:

Excluded:

  • Systemic and/or oral topical corticosteroids within 1 week prior to first set of bloods drawn.
  • Other putative immunomodulators within 2 weeks prior to study entry.
  • Prior thalidomide for aphthous ulcers.
Both
13 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States,   Puerto Rico
 
NCT00000790
ACTG 251, 11228
Not Provided
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Allergy and Infectious Diseases (NIAID)
Andrulis Pharmaceuticals
Study Chair: Jacobson JM
National Institute of Allergy and Infectious Diseases (NIAID)
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP