Treatment of Hypertension - Tabular View

Tracking Information

First Received Date ^ICMJE

October 27, 1999

Last Updated Date

June 23, 2005

Start Date ^ICMJE

April 1966

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00000484 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Treatment of Hypertension

Official Title ^ICMJE

Brief Summary

To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.

Detailed Description

BACKGROUND:

This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial.

DESIGN NARRATIVE:

Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo.

Study Phase

Phase III

Study Type ^ICMJE

Interventional

Study Design ^ICMJE

Prevention, Randomized, Double-Blind, Placebo Control

Condition ^ICMJE

Cardiovascular Diseases
Heart Diseases
Hypertension
Vascular Diseases

Intervention ^ICMJE

Drug: chlorothiazide
Drug: Rauwolfia alkaloids

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

Completion Date

Primary Completion Date

Eligibility Criteria ^ICMJE

Men and women, ages 21-55. Mild essential hypertension (diastolic blood pressure over 90 mm Hg.

Gender

Both

Ages

21 Years to 55 Years

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Administrative Information

NCT ID ^ICMJE

NCT00000484

Responsible Party

Study ID Numbers ^ICMJE

Study Sponsor ^ICMJE

National Heart, Lung, and Blood Institute (NHLBI)

Collaborators ^ICMJE

Investigators ^ICMJE

Investigator:	Anthony Damato	USPHS Hospital
Investigator:	Richard Thurm	USPHS Hospital
Investigator:	Christfried Urner	USPHS Hospital
Investigator:	John Vaillancourt	USPHS Hospital
Investigator:	J. Warbasse	USPHS Hospital
Investigator:	Robert Wells	USPHS Hospital

Information Provided By

National Heart, Lung, and Blood Institute (NHLBI)

Verification Date

January 2000

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP