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Ondansetron Treatment for Alcoholism
This study has been completed.
Study NCT00000443   Information provided by National Institute on Alcohol Abuse and Alcoholism (NIAAA)
First Received: November 2, 1999   Last Updated: June 23, 2005   History of Changes

November 2, 1999
June 23, 2005
 
 
 
 
Complete list of historical versions of study NCT00000443 on ClinicalTrials.gov Archive Site
 
 
 
Ondansetron Treatment for Alcoholism
Pharmacological Treatment for Alcoholism

The purpose of this study is to: a) evaluate the effectiveness of ondansetron (Zofran) in the treatment of alcohol dependent patients; b) investigate whether early versus late onset alcoholism predicts treatment outcome; and c) determine whether the early and late onset groups respond differently to treatment. Individuals will be "typed" into early onset and late onset alcoholism groups. Individuals will be randomly assigned to a 12-week outpatient treatment program.

 
Phase II
Interventional
Treatment, Randomized, Double-Blind, Placebo Control, Efficacy Study
Alcoholism
Drug: ondansetron (Zofran)
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
 
April 2000
 

Inclusion Criteria:

  • Meet criteria for alcohol dependence.
  • Subjects with early onset alcoholism must also have a diagnosis of antisocial personality disorder.
  • Understand the requirements of the study and be able to complete the questionnaires and rating scales.

Exclusion Criteria:

  • Current diagnosis of substance dependence or self-report of having used narcotics (opiates, cocaine, amphetamine-like substances, and hallucinogens) in the 30 day period prior to study.
  • Positive urine drug screen test for narcotics, barbiturates, or benzodiazepines.
  • Receiving current psychotropic medications.
  • Current history of other psychiatric disorders excluding nicotine dependence.
  • Hepatocellular disease.
  • Pregnant females.
Both
25 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00000443
 
NIAAAJOH10522
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 
 
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
August 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP