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Effects of Strength Training on Knee Osteoarthritis

This study has been completed.
Study NCT00000406.   Last updated on December 20, 2007.   Information provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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Descriptive Information Fields
Brief Title  Effects of Strength Training on Knee Osteoarthritis
Official Title  Effects of Strength Training on Knee Osteoarthritis (OA)
Brief Summary

To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.

Detailed Description

Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain.

In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.

Study Phase Phase II
Study Type  Interventional
Study Design  Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  Osteoarthritis, Knee
Intervention  Procedure: Progressive resistance exercise
MEDLINE PMIDs 17013851
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment  280
Start Date  September 1977
Completion Date November 2006
Eligibility Criteria 

Inclusion Criteria:

  • Males and females 60 to 100 years of age

Exclusion Criteria:

  • Knee joint replacement surgery
  • Diabetes mellitus
  • Uncontrollable hypertension
  • Neuropathies of the lower extremity
  • Poor mental cognition (i.e., inability to follow instructions)
Gender Both
Ages 60 Years and older
Accepts Healthy Volunteers Yes
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00000406
Organization ID P60 AR20582 Substudy EEHSR3
Secondary IDs †† NIAMS-022
Study Sponsor  National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborators ††
Investigators 
Principal Investigator:     Alan Mikesky, PhD     Indiana University School of Medicine    
Information Provided By National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Verification Date December 2007
First Received Date  November 3, 1999
Last Updated Date December 20, 2007

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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