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Effects of Strength Training on Knee Osteoarthritis
This study has been completed.
Study NCT00000406   Information provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
First Received: November 3, 1999   Last Updated: December 20, 2007   History of Changes

November 3, 1999
December 20, 2007
September 1977
November 2006   (final data collection date for primary outcome measure)
 
 
Complete list of historical versions of study NCT00000406 on ClinicalTrials.gov Archive Site
 
 
 
Effects of Strength Training on Knee Osteoarthritis
Effects of Strength Training on Knee Osteoarthritis (OA)

To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.

Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain.

In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.

Phase II
Interventional
Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study
Osteoarthritis, Knee
Procedure: Progressive resistance exercise
 
Mikesky AE, Mazzuca SA, Brandt KD, Perkins SM, Damush T, Lane KA. Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum. 2006 Oct 15;55(5):690-9.

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
280
November 2006
November 2006   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Males and females 60 to 100 years of age

Exclusion Criteria:

  • Knee joint replacement surgery
  • Diabetes mellitus
  • Uncontrollable hypertension
  • Neuropathies of the lower extremity
  • Poor mental cognition (i.e., inability to follow instructions)
Both
60 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00000406
 
P60 AR20582 Substudy EEHSR3, NIAMS-022
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
 
Principal Investigator: Alan Mikesky, PhD Indiana University School of Medicine
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
December 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP