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The Effects of Sex Hormones on Cognition and Mood in Older Adults
This study has been terminated.
Study NCT00000175   Information provided by National Institute on Aging (NIA)
First Received: October 29, 1999   Last Updated: June 23, 2005   History of Changes

October 29, 1999
June 23, 2005
 
 
 
 
Complete list of historical versions of study NCT00000175 on ClinicalTrials.gov Archive Site
 
 
 
The Effects of Sex Hormones on Cognition and Mood in Older Adults
 

This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.

Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).

 
Interventional
Treatment, Double-Blind, Placebo Control, Crossover Assignment
  • Cognition Disorders
  • Mood Disorders
  • Drug: Estrogen
  • Drug: Testosterone
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Terminated
 
 
 

Inclusion Criteria:

  • Women and men aged 65-90 who have not received hormone replacement for the last three months.

Exclusion Criteria:

  • Previous head injury with loss of consciousness for more than one hour.
  • Men with a history of prostate cancer.
  • Men on testosterone replacement within the past three months.
  • Women with a history of breast or uterine cancer.
  • Women on estrogen replacement within the past three months.
Both
65 Years to 90 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00000175
 
IA0016
National Institute on Aging (NIA)
 
Principal Investigator: Dr. Pauline Maki National Institute on Aging, Gerontology Research Center
National Institute on Aging (NIA)
March 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP