The Effects of Sex Hormones on Cognition and Mood in Older Adults - Tabular View

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The Effects of Sex Hormones on Cognition and Mood in Older Adults

This study has been terminated.

Study NCT00000175. Last updated on June 23, 2005. Information provided by National Institute on Aging (NIA)

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

The Effects of Sex Hormones on Cognition and Mood in Older Adults

Official Title ^†

Brief Summary

This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.

Detailed Description

Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).

Study Phase

Study Type ^†

Interventional

Study Design ^†

Treatment, Double-Blind, Placebo Control, Crossover Assignment

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Cognition Disorders
Mood Disorders

Intervention ^†

Drug: Estrogen
Drug: Testosterone

MEDLINE PMIDs

9153164, 8037876, 9153163

Links

Recruitment Information Fields

Recruitment Status ^†

Terminated

Enrollment ^†

Start Date ^†

Completion Date

Eligibility Criteria ^†

Inclusion Criteria:

Women and men aged 65-90 who have not received hormone replacement for the last three months.

Exclusion Criteria:

Previous head injury with loss of consciousness for more than one hour.
Men with a history of prostate cancer.
Men on testosterone replacement within the past three months.
Women with a history of breast or uterine cancer.
Women on estrogen replacement within the past three months.

Gender

Both

Ages

65 Years to 90 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Location Countries ^†

United States

Administrative Information Fields

NCT ID ^†

NCT00000175

Organization ID

IA0016

Secondary IDs ^††

Study Sponsor ^†

National Institute on Aging (NIA)

Collaborators ^††

Investigators ^†

Principal Investigator:

Dr. Pauline Maki

National Institute on Aging, Gerontology Research Center

Information Provided By

National Institute on Aging (NIA)

Verification Date

March 2004

First Received Date ^†

October 29, 1999

Last Updated Date

June 23, 2005

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.