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| Descriptive Information Fields | |||||
| Brief Title † | The Effects of Sex Hormones on Cognition and Mood in Older Adults | ||||
| Official Title † | |||||
| Brief Summary | This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn. |
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| Detailed Description | Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only). |
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| Study Phase | |||||
| Study Type † | Interventional | ||||
| Study Design † | Treatment, Double-Blind, Placebo Control, Crossover Assignment | ||||
| Primary Outcome Measure † | |||||
| Secondary Outcome Measure † | |||||
| Condition † | Cognition Disorders Mood Disorders |
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| Intervention † | Drug: Estrogen Drug: Testosterone |
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| MEDLINE PMIDs | 9153164, 8037876, 9153163 | ||||
| Links | |||||
| Recruitment Information Fields | |||||
| Recruitment Status † | Terminated | ||||
| Enrollment † | |||||
| Start Date † | |||||
| Completion Date | |||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||
| Ages | 65 Years to 90 Years | ||||
| Accepts Healthy Volunteers | Yes | ||||
| Contacts †† | |||||
| Location Countries † | United States | ||||
| Administrative Information Fields | |||||
| NCT ID † | NCT00000175 | ||||
| Organization ID | IA0016 | ||||
| Secondary IDs †† | |||||
| Study Sponsor † | National Institute on Aging (NIA) | ||||
| Collaborators †† | |||||
| Investigators † |
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| Information Provided By | National Institute on Aging (NIA) | ||||
| Verification Date | March 2004 | ||||
| First Received Date † | October 29, 1999 | ||||
| Last Updated Date | June 23, 2005 | ||||