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Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA
This study has been completed.
Study NCT00000110   Information provided by National Center for Research Resources (NCRR)
First Received: January 18, 2000   Last Updated: June 23, 2005   History of Changes

January 18, 2000
June 23, 2005
 
 
 
 
Complete list of historical versions of study NCT00000110 on ClinicalTrials.gov Archive Site
 
 
 
Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA
 

The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS) to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged bout of endurance running and, 2) determine the pattern (time course) of IML replenishment following an extremely low-fat diet (10% of energy from fat) and a moderate-fat diet (35% of energy from fat). Specifically, the study will evaluate the change in IML following a 2-hour training run and the recovery of IML in response to the post-exercise low-fat or moderate-fat diet in 10 endurance trained athletes who will consume both diets in a randomly assigned cross-over fashion. We hypothesize that IML will be depleted with prolonged endurance exercise, and that replenishment of IML will be impaired by an extremely low-fat diet compared to a moderate-fat diet. Results of this pilot study will be used to apply for extramural grant support from NIH or the US Armed Forces to investigate the effect of dietary fat on the health and performance of individuals performing heavy physical training. It is anticipated that this methodology could also be employed in obesity research to delineate, longitudinally, the reported cross-sectional relationships among IML stores, insulin resistance and obesity.

 
 
Interventional
Treatment, Single Blind
Obesity
  • Procedure: magnetic resonance spectroscopy
  • Drug: dietary fat
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
 
 
 

Inclusion Criteria:

  • Healthy volunteers (developmental phase)
  • Healthy endurance-trained subjects
  • Maximum age for males is 39
  • Maximum age for females is 49
Both
18 Years to 49 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00000110
 
NCRR-M01RR00032-0855, M01RR00032
National Center for Research Resources (NCRR)
 
 
National Center for Research Resources (NCRR)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP