Training Effects on Fuel Metabolism (TrainMeUpMN)
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental.
Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program.
Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).
Lean Trained Subjects
Overweight or Obese Subjects
Behavioral: Running Program
Behavioral: Yoga Program
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||Training Effects on Fuel Metabolism|
- Differences in insulin sensitivity between groups [ Time Frame: Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ] [ Designated as safety issue: No ]Will use HOMA-IR and hyperinsulinemia-euglycemic clamp
- Differences in fitness level between groups [ Time Frame: before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ] [ Designated as safety issue: No ]we will measure fitness level by treadmill based VO2 max testing.
- Differences in body composition between groups [ Time Frame: before and after exercise program ((exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ] [ Designated as safety issue: No ]we will measure body composition by iDEXA to look at changes and total fat, visceral fat, and subcutaneously pre-and post exercise. This will be a noninvasive x-ray based measurement (x-ray exposure is extremely low and is equivalent to 1 day of natural radiation in Minnesota)
|Study Start Date:||July 2014|
|Estimated Study Completion Date:||December 2018|
|Estimated Primary Completion Date:||December 2018 (Final data collection date for primary outcome measure)|
|No Intervention: Lean Trained|
Experimental: Obese or Overweight
Running Program Yoga Program
|Behavioral: Running Program Behavioral: Yoga Program|
Insulin resistance plays a critical role in the development of type 2 diabetes (T2DM), with skeletal muscle the largest site of insulin resistance in the human body. In sedentary humans, insulin resistance correlates with levels of intramyocellular lipid (IMCL) and lipid metabolites that adversely affect skeletal muscle glucose metabolism. However, even modest endurance training has been shown to reduce insulin resistance while increasing skeletal muscle IMCL. Moreover, lean endurance trained participants have IMCL levels comparable to those of patients with T2DM, yet have significantly lower insulin resistance. These findings suggest that the physiological changes caused by training protect against lipid induced insulin resistance and that this protection is present even at rest, however our preliminary data suggest that training facilitates utilization of readily available fuel, with lipid preferentially used over glucose when available. We will test the overarching hypothesis that training increases resting skeletal muscle lipid metabolism, as measured by markers of IMCL lipolysis, accumulation of fatty acid metabolites and mitochondrial utilization of fatty acids.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02150889
|Contact: Lisa S. Chow, MDfirstname.lastname@example.org|
|United States, Minnesota|
|University of Minnesota||Recruiting|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Lisa S. Chow, MD||University of Minnesota - Clinical and Translational Science Institute|