Trial record 11 of 75 for:    Cerebellar Degeneration

Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Ya-Ju Chang, Chang Gung University
ClinicalTrials.gov Identifier:
NCT02103075
First received: March 31, 2014
Last updated: NA
Last verified: March 2014
History: No changes posted
  Purpose

Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.


Condition Intervention
Spinocerebellar Ataxia
Device: Neuromuscular electrical stimulation

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Chang Gung University:

Primary Outcome Measures:
  • Central Motor Excitability [ Time Frame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes. ] [ Designated as safety issue: Yes ]
    Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.

  • Peripheral Motor Excitability [ Time Frame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes. ] [ Designated as safety issue: Yes ]
    Measure of changes in peripheral motor excitability by Maximum M wave and H reflex


Enrollment: 29
Study Start Date: August 2002
Study Completion Date: October 2005
Primary Completion Date: October 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: The SCA Device: Neuromuscular electrical stimulation
All groups received an accumulated 30-minute NMES (25 Hz, on/off: 800ms/800ms) intervention on median nerve.
Experimental: The age-matched control Device: Neuromuscular electrical stimulation
All groups received an accumulated 30-minute NMES (25 Hz, on/off: 800ms/800ms) intervention on median nerve.
Experimental: The young control Device: Neuromuscular electrical stimulation
All groups received an accumulated 30-minute NMES (25 Hz, on/off: 800ms/800ms) intervention on median nerve.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Spinocerebellar ataxia
  • No history of epilepsy
  • No other neuromuscular disorder
  • No fracture within the last six months and restricted movement on the upper extremity
  • Limited trembling hand allowed for the EMG recording.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT02103075

Locations
Taiwan
Chang Gung University
Taoyuan, Taiwan, 333
Sponsors and Collaborators
Chang Gung University
  More Information

No publications provided

Responsible Party: Ya-Ju Chang, Professor, Chang Gung University
ClinicalTrials.gov Identifier: NCT02103075     History of Changes
Other Study ID Numbers: 91-221
Study First Received: March 31, 2014
Last Updated: March 31, 2014
Health Authority: Taiwan: Department of Health

Keywords provided by Chang Gung University:
spinocerebellar ataxia (SCA)
motor evoked potential (MEP)
Neuromuscular electrical stimulation (NMES)
silent period
cerebellum

Additional relevant MeSH terms:
Spinocerebellar Degenerations
Cerebellar Ataxia
Cerebellar Diseases
Ataxia
Spinocerebellar Ataxias
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Spinal Cord Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on October 01, 2014