Gene Expression in the Overactive Bladder in Children
The aim of this study (the hypothesis) is to identify differences in the gene expression profile in the bladder muscle and hereby gain greater knowledge about the muscular mechanisms that cause overactive bladder and daytime urinary incontinence in children older than 5 years. A secondary aim is to examine how this gene expression profile differs from children with a neurogenic overactive bladder and how the gene expression profile changes from childhood till adulthood. Such new knowledge will result in a more precisely targeted and hence effective treatment of overactive bladder.
The results will be obtained by retrieving bladder biopsies from children and adults suffering from an overactive bladder or a neurogenic bladder. These biopsies will undergo molecular analysis and the investigators will compare them with biopises from bladder healthy adults and children.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Gene Expression in the Bladder in Children With an Overactive Bladder and Daytime Urinary Incontinence|
- Up- and down regulation of genes expressed in the bladder [ Time Frame: collection of bladder material and analysis will take approximately 2 years ] [ Designated as safety issue: No ]We will evaluate the gene expression (which genes are up- and/or down regulated) in the bladder in healthy children compared to children suffering from an overactive bladder. This gene expression will then be compared to the gene expression in bladder tissue from adults, to evaluate what happens in the bladder from childhood to adulthood.
Biospecimen Retention: Samples With DNA
Bladder biopsies from the back-wall og the bladder.
|Study Start Date:||November 2013|
|Estimated Study Completion Date:||November 2016|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT02086058
|Contact: Luise Borch, M.D||+45 22 92 55 firstname.lastname@example.org|
|Center for child incontinence, Aarhus University hospital||Recruiting|
|Aarhus, Aarhus N, Denmark, 8200|
|Principal Investigator:||Luise Borch, M.D||University of Aarhus|