Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Anna Bugge, Post Doc, University of Southern Denmark
ClinicalTrials.gov Identifier:
NCT02075944
First received: February 27, 2014
Last updated: June 25, 2014
Last verified: June 2014
  Purpose

The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.


Condition Intervention
Physical Conditioning, Human
Cognition
Behavioral: High intensity aerobic exercise
Behavioral: Low intensity aerobic exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Supportive Care
Official Title: Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults Aged 15-21 Years

Resource links provided by NLM:


Further study details as provided by University of Southern Denmark:

Primary Outcome Measures:
  • The Flanker Task [ Time Frame: 9 weeks ] [ Designated as safety issue: No ]
  • The AX-Continuous Performance test [ Time Frame: 9 weeks ] [ Designated as safety issue: No ]
  • Brain-derived neurotrophic factor [ Time Frame: 9 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Intelligence quotient [ Time Frame: 9 weeks ] [ Designated as safety issue: No ]

Enrollment: 130
Study Start Date: February 2014
Study Completion Date: June 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: High intensity aerobic exercise
30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training
Behavioral: High intensity aerobic exercise
Experimental: Low intensity aerobic exercise
30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks
Behavioral: Low intensity aerobic exercise
No Intervention: Control
No intervention. Participants are told not to make any changes in their everyday life

  Eligibility

Ages Eligible for Study:   15 Years to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 15-21

Exclusion Criteria:

  • injury preventing one from being physically active
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02075944

Locations
Denmark
University of Southern Denmark
Odense, Denmark, 5000
Sponsors and Collaborators
University of Southern Denmark
Investigators
Principal Investigator: Anne K Thorsen, Cand. Scient University of Southern Denmark
  More Information

No publications provided

Responsible Party: Anna Bugge, Post Doc, PhD, University of Southern Denmark
ClinicalTrials.gov Identifier: NCT02075944     History of Changes
Other Study ID Numbers: S-20130171
Study First Received: February 27, 2014
Last Updated: June 25, 2014
Health Authority: Denmark: Ethics Committee
Denmark: Danish Dataprotection Agency

Keywords provided by University of Southern Denmark:
Aerobic exercise
Cognitive function
Executive function
Brain-derived neurotrophic factor

ClinicalTrials.gov processed this record on September 16, 2014