Postoperative Respiratory Depression After Cardiac Surgery (CABG PRD)
This study has been completed.
Information provided by (Responsible Party):
Ovidiu Constantin Baltatu, Universidade Castelo Branco
First received: February 26, 2014
Last updated: February 27, 2014
Last verified: February 2014
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory function impairment.
||Observational Model: Case-Crossover
Time Perspective: Prospective
||Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery
Primary Outcome Measures:
Secondary Outcome Measures:
- Intraoperative parameters after coronary artery bypass graft surgery (CABG) [ Time Frame: 1 day ] [ Designated as safety issue: No ]
Intraoperative parameters are monitored, including volume of cardioplegia, CPB duration, aortic cross-clamp time, number of grafts.
- Perioperative parameters after coronary artery bypass graft surgery (CABG) [ Time Frame: 3 days ] [ Designated as safety issue: No ]
ICU blood pressure is monitored
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||June 2012 (Final data collection date for primary outcome measure)
Coronary artery bypass graft (CABG) surgery is a principal revascularization option for ischemic heart disease and the principal modality for invasive treatment of coronary artery disease. Postoperative pulmonary complications are the most frequent and significant contributor to length of hospitalization, morbidity and mortality. The objective of this study is to search for perioperative parameters that could predict the degree of impairment of respiratory function after CABG with cardiopulmonary bypass (CPB).
|Ages Eligible for Study:
||18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Patients with coronary artery disease submitted to elective CABG with CPB.
- patients of both sexes older than 18 years submitted to CABG with CPB, presence of coronary disease confirmed by coronary angiography, use of the left internal thoracic artery and/or saphena, patients who remained in spontaneous ventilation on the first postoperative day, absence of chronic or acute pulmonary disease, and giving written informed consent to participate in the study.
- intraoperative change of the surgical technique, surgical complications or complications occurring in the ICU, emergency reoperation, renal failure, failure to agree to continue in the study, presence of other types of heart disease, and presence of pulmonary diseases.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02074371
|Hospital Sao Marcos
|Teresina, Piauí, Brazil, 64001-280 |
Ovidiu Constantin Baltatu
||Ovidiu C Baltatu, MD PhD
||Camilo Castelo Branco University (UNICASTELO)
No publications provided
||Ovidiu Constantin Baltatu, Professor, Universidade Castelo Branco
History of Changes
|Other Study ID Numbers:
|Study First Received:
||February 26, 2014
||February 27, 2014
||Brazil: National Committee of Ethics in Research
Keywords provided by Universidade Castelo Branco:
coronary artery bypass surgery
postoperative respiratory depression
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 18, 2014
Coronary Artery Disease
Arterial Occlusive Diseases
Respiratory Tract Diseases